First Report on Association of Hyperuricemia with Type 2 Diabetes in a Vietnamese Population
Joint Authors
Binh, Tran Quang
Tran Phuong, Pham
Thanh Chung, Nguyen
Nhung, Bui Thi
Tung, Do Dinh
Quang Thuyen, Tran
Tuan Linh, Duong
Thuy Nga, Bui Thi
Anh Ngoc, Nguyen
Danh Tuyen, Le
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Uric acid is a powerful free-radical scavenger in humans, but hyperuricemia may induce insulin resistance and beta-cell dysfunction.
The study aimed to evaluate the association between hyperuricemia and hyperglycemia, considering the confounding factors in a Vietnamese population.
Methods.
A population-based cross-sectional study recruited 1542 adults aged 50 to 70 years to collect data on socioeconomic status, lifestyle factors, and clinical patterns.
Associations between hyperuricemia and hyperglycemia (isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT), combined IFG-IGT, and type 2 diabetes (T2D)) were evaluated by multinomial logistic regression analysis in several models, adjusting for the confounding factors including socioeconomic status, lifestyle factors, and clinical measures.
Results.
Uric acid values were much higher in IFG, IFG-IGT, and T2D groups compared to those in the normal glucose tolerance (NGT) group.
The significant association of hyperuricemia with IFG, IFG-IGT, and T2D was found in the model unadjusted and remained consistently in several models adjusted for socioeconomic status, lifestyle factors, and clinical patterns.
In the final model, the consistent hyperglycemia risk was found in total sample (OR = 2.23 for IFG, OR = 2.29 for IFG-IGT, and 1.75 for T2D, P≤0.006) and in women (OR = 2.90 for IFG, OR = 3.96 for IFG-IGT, and OR = 2.49 for T2D, P<0.001) but not in men.
Conclusions.
It is the first report in Vietnamese population suggesting the significant association of hyperuricemia with IFG, IFG-IGT, and T2D; and the predominant association was found in women than in men, taken into account the confounding factors.
American Psychological Association (APA)
Binh, Tran Quang& Tran Phuong, Pham& Thanh Chung, Nguyen& Nhung, Bui Thi& Tung, Do Dinh& Quang Thuyen, Tran…[et al.]. 2019. First Report on Association of Hyperuricemia with Type 2 Diabetes in a Vietnamese Population. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1159592
Modern Language Association (MLA)
Binh, Tran Quang…[et al.]. First Report on Association of Hyperuricemia with Type 2 Diabetes in a Vietnamese Population. International Journal of Endocrinology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1159592
American Medical Association (AMA)
Binh, Tran Quang& Tran Phuong, Pham& Thanh Chung, Nguyen& Nhung, Bui Thi& Tung, Do Dinh& Quang Thuyen, Tran…[et al.]. First Report on Association of Hyperuricemia with Type 2 Diabetes in a Vietnamese Population. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1159592
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159592