Immunohistochemical Study of NR2C2, BTG2, TBX19, and CDK2 Expression in 31 Paired PrimaryRecurrent Nonfunctioning Pituitary Adenomas
Joint Authors
Zhang, Yazhuo
Yao, Xiaohui
Wu, Lijuan
Cheng, Rui
Li, Chuzhong
Qu, Chongxiao
Ji, Hongming
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study investigated potential markers for predicting nonfunctioning pituitary adenoma (NFPA) invasion and recurrence by high-throughput tissue microarray analyses.
We retrospectively studied two groups of patients: 60 nonrecurrent NFPA cases that included noninvasion and invasion subtypes and 43 recurrent cases that included primary NFPA.
A total of 31 paired patient samples were evaluated (12 patients with one surgery and 31 who had undergone two operations, with both tumors analyzed).
Expressions of nuclear receptor subfamily 2 group C member 2 (NR2C2), B cell translocation gene 2, T-box-19 (TBX19), and cyclin-dependent kinase 2 (CDK2) in surgically resected specimens were assessed by immunohistochemistry.
The relationships between marker expression and clinical characteristics including age, sex, tumor volume, and follow-up time were analyzed.
Tumor volume and invasion as well as follow-up time were significantly associated with invasion and recurrence (P < 0.01).
Of the 60 nonrecurrent samples, 15/41 and 13/19 showed high NR2C2 expression in the noninvasion and invasion groups, respectively (χ2 =5.287, P = 0.021).
NR2C2 was also overexpressed in 43 primary recurrent cases (χ2 =5.433, P = 0.02), whereas CDK2 (χ2 = 11.242, P = 0.001) and TBX19 (χ2 = 4.875, P = 0.027) were downregulated.
In the 31 paired samples, NR2C2 was more highly expressed in the recurrent as compared to the primary tumor.
High NR2C2 expression was associated with NFPA invasion, recurrence, and progression, while TBX19 and CDK2 were associated with NFPA recurrence.
American Psychological Association (APA)
Yao, Xiaohui& Zhang, Yazhuo& Wu, Lijuan& Cheng, Rui& Li, Chuzhong& Qu, Chongxiao…[et al.]. 2019. Immunohistochemical Study of NR2C2, BTG2, TBX19, and CDK2 Expression in 31 Paired PrimaryRecurrent Nonfunctioning Pituitary Adenomas. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1159615
Modern Language Association (MLA)
Yao, Xiaohui…[et al.]. Immunohistochemical Study of NR2C2, BTG2, TBX19, and CDK2 Expression in 31 Paired PrimaryRecurrent Nonfunctioning Pituitary Adenomas. International Journal of Endocrinology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1159615
American Medical Association (AMA)
Yao, Xiaohui& Zhang, Yazhuo& Wu, Lijuan& Cheng, Rui& Li, Chuzhong& Qu, Chongxiao…[et al.]. Immunohistochemical Study of NR2C2, BTG2, TBX19, and CDK2 Expression in 31 Paired PrimaryRecurrent Nonfunctioning Pituitary Adenomas. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1159615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159615