Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture
Joint Authors
Robertson, Stephen P.
Sun, Xi
Guo, Qi
Wei, Wenhua
Yuan, Ying
Luo, Xianghang
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-06
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Emerging evidence demonstrates that microRNAs, as important endogenous posttranscriptional regulators, are essential for bone remodeling and regeneration.
Undoubtedly, microRNA-based gene therapies show great potential to become novel approaches against bone-related diseases, including osteoporosis and associated fractures.
The major obstacles for continued advancement of microRNA-based therapies in clinical application include their poor in vivo stability, nonspecific biodistribution, and unwanted side effects.
Appropriate chemical modifications and delivery vectors, which improve the biological performance and potency of microRNA-based drugs, hold the key to translating miRNA technologies into clinical practice.
Thus, this review summarizes the current attempts and existing deficiencies of chemical modifications and delivery systems applied in microRNA-based therapies for osteoporosis and osteoporotic fractures to inform further explorations.
American Psychological Association (APA)
Sun, Xi& Guo, Qi& Wei, Wenhua& Robertson, Stephen P.& Yuan, Ying& Luo, Xianghang. 2019. Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1159655
Modern Language Association (MLA)
Sun, Xi…[et al.]. Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture. International Journal of Endocrinology No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1159655
American Medical Association (AMA)
Sun, Xi& Guo, Qi& Wei, Wenhua& Robertson, Stephen P.& Yuan, Ying& Luo, Xianghang. Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1159655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159655