Prognostic Analysis of Duodenal Gastrointestinal Stromal Tumors
Joint Authors
Zhang, Tianyu
Wang, Zhengting
Fan, Rong
Zhang, Maochen
Hong, Liwen
Zhou, Xiaolin
Cheng, Mengmeng
Zhong, Jie
Lin, Yun
Sun, Peijun
Sun, Juntao
Wu, Qiangqiang
Wang, Lei
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
This study aims to analyze factors possibly related to the prognosis of duodenal gastrointestinal stromal tumors (DGISTs).
Methods.
We collected and retrospectively analyzed clinical and pathological data of 62 patients with primary DGISTs.
All the patients were hospitalized and received complete surgical resection at Shanghai Ruijin Hospital from September 2003 to April 2015.
We followed up the patients to determine survival outcomes.
We also analyzed the effect of clinical and pathological factors on disease-free survival (DFS) and overall survival (OS) of the patients.
Results.
Kaplan-Meier univariate survival analysis demonstrated that tumor size, mitotic index, Ki-67 index, and pathological risk were correlated with the DFS and OS of the patients (DFS P=0.039, 0.001, <0.001, and 0.005, resp.; OS P=0.027, 0.007, <0.001, and 0.012, resp.).
Cox multivariate regression analysis revealed that Ki-67 index was an independent prognostic factor affecting DFS and OS (P=0.007 and 0.028, resp.).
Moreover, Kaplan-Meier survival analysis showed that imatinib treatment for patients with recurrence was correlated with prolonged OS (P=0.002).
Conclusion.
Prognosis for DGIST treated by R0 resection is favorable.
High level of Ki-67 can be an independent risk factor of DGIST prognosis.
Adjuvant imatinib therapy for patients with tumor recurrence could probably lead to prolonged survival.
American Psychological Association (APA)
Hong, Liwen& Zhang, Tianyu& Lin, Yun& Fan, Rong& Zhang, Maochen& Cheng, Mengmeng…[et al.]. 2018. Prognostic Analysis of Duodenal Gastrointestinal Stromal Tumors. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1159737
Modern Language Association (MLA)
Hong, Liwen…[et al.]. Prognostic Analysis of Duodenal Gastrointestinal Stromal Tumors. Gastroenterology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1159737
American Medical Association (AMA)
Hong, Liwen& Zhang, Tianyu& Lin, Yun& Fan, Rong& Zhang, Maochen& Cheng, Mengmeng…[et al.]. Prognostic Analysis of Duodenal Gastrointestinal Stromal Tumors. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1159737
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159737