Encapsulation of Nicardipine Hydrochloride and Release from Biodegradable Poly(D,L-lactic-co-glycolic acid) Microparticles by Double Emulsion Process: Effect of Emulsion Stability and Different Parameters on Drug Entrapment
Joint Authors
Chumnanvej, Sorayouth
Soomherun, Nopparuj
Kreua-ongarjnukool, Narumol
Thumsing, Saowapa
Source
International Journal of Biomaterials
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Poly(D,L-lactic-co-glycolic acid) (PLGA) is an important material used in drug delivery when controlled release is required.
The purpose of this research is to design and characterize PLGA microparticles (PLGA MPs) implants for the controlled release of nicardipine hydrochloride (NCH) in vitro.
This study used the water-in-oil-in-water (w1/o/w2) double emulsion and solvent diffusion/evaporation approach to prepare PLGA MPs.
Optimal processing conditions were found, such as polymer content, surfactant type, stabilizer concentration, inner and outer aqueous phase volumes, and stirring speed.
The PLGA MPs for use as nicardipine hydrochloride (NCH) loading and release had spherical morphology, and the average diameter was smaller than 5.20±0.25 μm.
The release kinetics were modeled to elucidate the possible mechanism of drug release.
In vitro release studies indicated that the NCH release rate is slow and continuous.
PLGA MPs are an interesting alternative drug delivery system, especially for use with NCH for biomedical applications.
American Psychological Association (APA)
Soomherun, Nopparuj& Kreua-ongarjnukool, Narumol& Chumnanvej, Sorayouth& Thumsing, Saowapa. 2017. Encapsulation of Nicardipine Hydrochloride and Release from Biodegradable Poly(D,L-lactic-co-glycolic acid) Microparticles by Double Emulsion Process: Effect of Emulsion Stability and Different Parameters on Drug Entrapment. International Journal of Biomaterials،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1160066
Modern Language Association (MLA)
Soomherun, Nopparuj…[et al.]. Encapsulation of Nicardipine Hydrochloride and Release from Biodegradable Poly(D,L-lactic-co-glycolic acid) Microparticles by Double Emulsion Process: Effect of Emulsion Stability and Different Parameters on Drug Entrapment. International Journal of Biomaterials No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1160066
American Medical Association (AMA)
Soomherun, Nopparuj& Kreua-ongarjnukool, Narumol& Chumnanvej, Sorayouth& Thumsing, Saowapa. Encapsulation of Nicardipine Hydrochloride and Release from Biodegradable Poly(D,L-lactic-co-glycolic acid) Microparticles by Double Emulsion Process: Effect of Emulsion Stability and Different Parameters on Drug Entrapment. International Journal of Biomaterials. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1160066
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1160066