Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHSDRESS
Joint Authors
Li, Yu-xiu
Xiao, Xinhua
Deng, Mingqun
Wu, Han
Yu, Miao
Tian, Yi
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe adverse reaction caused by specific drugs.
However, little information is available about sequelae following DIHS/DRESS resolution from an endocrinologist’s perspective.
This study aimed to investigate the endocrine sequelae following DIHS/DRESS, from clinical feature to etiology.
Methods.
We retrospectively analyzed the patients diagnosed with DIHS/DRESS in Peking Union Medical College Hospital (PUMCH) during the period of 1 January 2012 to 31 December 2017, and those who developed endocrine disorders after DIHS/DRESS were further examined.
We also reviewed the literature, from 1 January 2000 to 31 December 2017, on involvement of endocrine glands in DIHS/DRESS patients.
Results.
Three patients developed both autoimmune thyroid disease (AITD) and type 1 diabetes (T1DM)/fulminant type 1 diabetes (FT1DM) of the 45 patients.
Seven cases involving more than two endocrine glands were reported in the literature.
Our results indicated that DIHS/DRESS is a potential etiological factor of autoimmune polyendocrine syndrome (APS), especially APS III.
Conclusions.
Patients require careful long-term follow-up after DIHS/DRESS.
Involvement of endocrine glands, especially FT1DM, should always be monitored in patients with a history of DIHS/DRESS.
This study indicated that DIHS/DRESS could lead to APS, especially APS III, providing novel insights into the etiological factors of APS.
American Psychological Association (APA)
Deng, Mingqun& Wu, Han& Yu, Miao& Tian, Yi& Li, Yu-xiu& Xiao, Xinhua. 2019. Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHSDRESS. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1160067
Modern Language Association (MLA)
Deng, Mingqun…[et al.]. Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHSDRESS. International Journal of Endocrinology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1160067
American Medical Association (AMA)
Deng, Mingqun& Wu, Han& Yu, Miao& Tian, Yi& Li, Yu-xiu& Xiao, Xinhua. Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHSDRESS. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1160067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1160067