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Fabrication of PolycaprolactonePolyurethane Loading Conjugated Linoleic Acid and Its Antiplatelet Adhesion
Joint Authors
Hiep, Nguyen Thi
Hai, Nguyen Dai
Minh, Ho Hieu
Toi, Vo Van
Source
International Journal of Biomaterials
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Polycaprolactone/polyurethane (PCL/PU) fibrous scaffold was loaded with conjugated linoleic acid (CLA) by electrospinning method to improve the hemocompatibility of the polymeric surface.
Fourier Transform Infrared Spectroscopy (FT-IR) analysis and Scanning Electron Microscopy (SEM) observation were employed to characterize the chemical structure and the changing morphology of electrospun PCL/PU and PCL/PU loaded with CLA (PCL/PU-CLA) scaffolds.
Platelet adhesion and whole blood clot formation tests were used to evaluate the effect of CLA on antithrombotic property of PCL/PU-CLA scaffold.
Endothelial cells (EC) were also seeded on the scaffold to examine the difference in the morphology of EC layer and platelet attachment with and without the presence of CLA.
SEM results showed that CLA supported the spreading and proliferation of EC and PCL/PU-CLA surface induced lower platelet adhesion as well as attachment of other blood cells compared to the PCL/PU one.
These results suggest that electrospinning method can successfully combine the antiplatelet effects of CLA to improve hemocompatibility of PCL/PU scaffolds for applications in artificial blood vessels.
American Psychological Association (APA)
Minh, Ho Hieu& Hiep, Nguyen Thi& Hai, Nguyen Dai& Toi, Vo Van. 2017. Fabrication of PolycaprolactonePolyurethane Loading Conjugated Linoleic Acid and Its Antiplatelet Adhesion. International Journal of Biomaterials،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1160081
Modern Language Association (MLA)
Minh, Ho Hieu…[et al.]. Fabrication of PolycaprolactonePolyurethane Loading Conjugated Linoleic Acid and Its Antiplatelet Adhesion. International Journal of Biomaterials No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1160081
American Medical Association (AMA)
Minh, Ho Hieu& Hiep, Nguyen Thi& Hai, Nguyen Dai& Toi, Vo Van. Fabrication of PolycaprolactonePolyurethane Loading Conjugated Linoleic Acid and Its Antiplatelet Adhesion. International Journal of Biomaterials. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1160081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1160081