Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel
Joint Authors
Hai, Nguyen Dai
Nguyen, Thi Hiep
Nguyen, Thi Lan
Source
International Journal of Biomaterials
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The formulation of a potential delivery system based on liposomes (Lips) formulated from soy lecithin (SL) for paclitaxel (PTX) was achieved (PTX-Lips).
At first, PTX-Lips were prepared by thin film method using SL and cholesterol and then were characterized for their physiochemical properties (particle size, polydispersity index, zeta potential, and morphology).
The results indicated that PTX-Lips were spherical in shape with a dynamic light scattering (DLS) particle size of 131±30.5 nm.
Besides, PTX was efficiently encapsulated in Lips, 94.5±3.2% for drug loading efficiency, and slowly released up to 96 h, compared with free PTX.
More importantly, cell proliferation kit I (MTT) assay data showed that Lips were biocompatible nanocarriers, and in addition the incorporation of PTX into Lips has been proven successful in reducing the toxicity of PTX.
As a result, development of Lips using SL may offer a stable delivery system and promising properties for loading and sustained release of PTX in cancer therapy.
American Psychological Association (APA)
Nguyen, Thi Lan& Nguyen, Thi Hiep& Hai, Nguyen Dai. 2017. Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel. International Journal of Biomaterials،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1160094
Modern Language Association (MLA)
Nguyen, Thi Lan…[et al.]. Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel. International Journal of Biomaterials No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1160094
American Medical Association (AMA)
Nguyen, Thi Lan& Nguyen, Thi Hiep& Hai, Nguyen Dai. Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel. International Journal of Biomaterials. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1160094
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1160094