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Glucocorticoid Receptor Antagonist Administration Prevents Adrenal Gland Atrophy in an ACTH-Independent Cushing’s Syndrome Rat Model
Joint Authors
Yasuda, Atsushi
Seki, Toshiro
Kametani, Yoshie
Koizumi, Masahiro
Kitajima, Natsumi
Oki, Masayuki
Seki, Masami
Kakuta, Takatoshi
Fukagawa, Masafumi
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
ACTH-independent Cushing’s syndrome (CS) is mainly caused by cortisol-secreting adrenocortical tumours.
It is well known that secondary adrenal insufficiency occurs after surgical resection of these tumours.
In this regard, impaired adrenocortical function is likely induced by atrophy of the residual adrenal tissue as a result of chronic suppression by the low ACTH levels of the hypercortisolism state.
Therefore, we considered the prevention of adrenal atrophy as a method for preventing postoperative adrenal insufficiency.
On the basis of these findings, we hypothesized that the use of a glucocorticoid receptor (GR) antagonist before surgery in ACTH-independent CS would rapidly activate the hypothalamic-pituitary-adrenal (HPA) axis and residual adrenal function.
We thus examined adrenal function in a dexamethasone- (DEX-) induced CS rat model with or without mifepristone (MIF).
In this study, MIF-treated rats had elevated plasma ACTH levels and increased adrenal weights.
In addition, we confirmed that there were fewer atrophic changes, as measured by the pathological findings and mRNA expression levels of corticosterone synthase CYP11B1 in the adrenal glands, in MIF-treated rats.
These results indicate that MIF treatment prevents the suppression of the HPA axis and the atrophy of the residual adrenal tissue.
Therefore, our study suggests that preoperative GR antagonist administration may improve residual adrenal function and prevent postoperative adrenal insufficiency in ACTH-independent CS.
American Psychological Association (APA)
Yasuda, Atsushi& Seki, Toshiro& Kametani, Yoshie& Koizumi, Masahiro& Kitajima, Natsumi& Oki, Masayuki…[et al.]. 2019. Glucocorticoid Receptor Antagonist Administration Prevents Adrenal Gland Atrophy in an ACTH-Independent Cushing’s Syndrome Rat Model. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1165058
Modern Language Association (MLA)
Yasuda, Atsushi…[et al.]. Glucocorticoid Receptor Antagonist Administration Prevents Adrenal Gland Atrophy in an ACTH-Independent Cushing’s Syndrome Rat Model. International Journal of Endocrinology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1165058
American Medical Association (AMA)
Yasuda, Atsushi& Seki, Toshiro& Kametani, Yoshie& Koizumi, Masahiro& Kitajima, Natsumi& Oki, Masayuki…[et al.]. Glucocorticoid Receptor Antagonist Administration Prevents Adrenal Gland Atrophy in an ACTH-Independent Cushing’s Syndrome Rat Model. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1165058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165058