Endoscopic Injection of Mitomycin C for the Treatment of Pharyngoesophageal Stenosis Refractory to Endoscopic Treatment with Dilatation in Patients Treated for Head and Neck Cancer
Joint Authors
Ribeiro Jr., Ulysses
Gusmon-Oliveira, Carla Cristina
Kuboki, Yeda Mayumi
de Paulo, Gustavo Andrade
de Lima, Marcelo Simas
Uemura, Ricardo Sato
Martins, Bruno Costa
Tolentino, Luciano Lenz
Safatle-Ribeiro, Adriana Vaz
Kulcsar, Marco Aurelio
Maluf-Filho, Fauze
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Management of pharyngoesophageal stenosis (PES) in patients after head and neck cancer (HNC) treatment remains a challenge.
It is not uncommon that PES is refractory to dilation sessions.
This study aimed at evaluating the efficacy of Mitomycin C (MMC) endoscopic injection for the treatment of refractory pharyngoesophageal stenosis.
Patients and methods.
This is a prospective study in patients with dysphagia following head and neck cancer treatment, without evidence suggestive of tumor recurrence, and refractory to endoscopic treatment.
These patients were submitted to endoscopic dilation of the stenotic segment with thermoplastic bougies, followed by injection of MMC.
We repeated the endoscopic sessions every three weeks.
Results.
From January 2015 to May 2015, we treated 13 patients with PES.
Three patients were initially enrolled in the study for refractory stricture.
We observed adverse events in all of them, with intense neck pain and ulcer development, justifying the interruption of the trial.
Conclusion.
The repeated injection in the short interval of MMC in refractory PES is not recommended, because it resulted in serious adverse events.
American Psychological Association (APA)
Gusmon-Oliveira, Carla Cristina& Kuboki, Yeda Mayumi& de Paulo, Gustavo Andrade& de Lima, Marcelo Simas& Uemura, Ricardo Sato& Martins, Bruno Costa…[et al.]. 2018. Endoscopic Injection of Mitomycin C for the Treatment of Pharyngoesophageal Stenosis Refractory to Endoscopic Treatment with Dilatation in Patients Treated for Head and Neck Cancer. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1165083
Modern Language Association (MLA)
Gusmon-Oliveira, Carla Cristina…[et al.]. Endoscopic Injection of Mitomycin C for the Treatment of Pharyngoesophageal Stenosis Refractory to Endoscopic Treatment with Dilatation in Patients Treated for Head and Neck Cancer. Gastroenterology Research and Practice No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1165083
American Medical Association (AMA)
Gusmon-Oliveira, Carla Cristina& Kuboki, Yeda Mayumi& de Paulo, Gustavo Andrade& de Lima, Marcelo Simas& Uemura, Ricardo Sato& Martins, Bruno Costa…[et al.]. Endoscopic Injection of Mitomycin C for the Treatment of Pharyngoesophageal Stenosis Refractory to Endoscopic Treatment with Dilatation in Patients Treated for Head and Neck Cancer. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1165083
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165083