The Association of Autoantibodies in Hyperthyroid Heart Disease Combined with Pulmonary Hypertension
Joint Authors
Zhang, Xiujuan
Chen, Lin
Sheng, Jianping
Li, Chaoying
He, Yong
Han, WenXia
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Hyperthyroidism is a clinical state that results from increased thyroid hormone levels which has a significant impact on cardiac function and structure.
Graves’ disease is the most common cause of hyperthyroidism in iodine-replete areas.
Hyperthyroid heart disease may be associated with pulmonary hypertension in patients who have overt hyperthyroidism.
To investigate the association of pulmonary hypertension induced by hyperthyroid heart disease and autoantibody, one hundred and one cases with hyperthyroid heart disease who were consecutively admitted to the inpatient department of endocrinology and metabolism of the Shandong Provincial Hospital between November 2014 and April 2018 were collected and analyzed statistically.
According to the Independent samples T-test, variance analysis, chi-square test, Pearson linear correlation analysis, and logistic regression, there was a good correlation between pulmonary artery systolic pressure and thyroid stimulating hormone (TSH) and receptor antibodies (TRAb) (r = 0.264, P=0.025) (OR = 1.037, P=0.029), but there was no significant correlation between the pulmonary artery systolic pressure and other thyroid-related parameters (FT3, FT4, TSH, anti-TPO, and anti-TG).
Based on variance analysis, PASP rose as the level of TRAb gets higher.
What is more, patients with HHD combined with PH showed a significantly higher serum level of TRAb; moreover, serum TRAb concentration was remarkably correlated with the PASP level.
Therefore, TRAb participates in the process of pulmonary hypertension caused by hyperthyroid heart disease.
American Psychological Association (APA)
Zhang, Xiujuan& Chen, Lin& Sheng, Jianping& Li, Chaoying& He, Yong& Han, WenXia. 2019. The Association of Autoantibodies in Hyperthyroid Heart Disease Combined with Pulmonary Hypertension. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1165120
Modern Language Association (MLA)
Zhang, Xiujuan…[et al.]. The Association of Autoantibodies in Hyperthyroid Heart Disease Combined with Pulmonary Hypertension. International Journal of Endocrinology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1165120
American Medical Association (AMA)
Zhang, Xiujuan& Chen, Lin& Sheng, Jianping& Li, Chaoying& He, Yong& Han, WenXia. The Association of Autoantibodies in Hyperthyroid Heart Disease Combined with Pulmonary Hypertension. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1165120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165120