Integrated Bioinformatics Analysis of Hub Genes and Pathways in Anaplastic Thyroid Carcinomas
Joint Authors
Gao, Xueren
Wang, Jianguo
Zhang, Shulong
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Anaplastic thyroid carcinoma (ATC) is a very rare malignancy; the pathogenesis of which is still not fully understood.
The aim of the present study was to identify hub genes and pathways in ATC by microarray expression profiling.
Two independent datasets (GSE27155 and GSE53072) were downloaded from GEO database.
The differentially expressed genes (DEGs) between ATC tissues and normal thyroid tissues were screened out by the limma package and then enriched by gene ontology (GO) and KEGG pathway analysis.
The hub genes were selected by protein-protein interaction (PPI) analysis.
A total of 141 common upregulated and 87 common downregulated genes were screened out.
These DEGs were significantly enriched in the phagosome and NF-kappa B signaling pathway.
Through PPI analysis, TOP2A, TYMS, CCNB1, RACGAP1, FEN1, PRC1, and UBE2C were selected as hub genes, which were highly expressed in ATC tissues.
TCGA data suggested that the expression levels of TOP2A, TYMS, FEN1, and PRC1 genes were also upregulated in other histological subtypes of thyroid carcinoma.
High expression of TOP2A, TYMS, FEN1, PRC1, or UBE2C gene significantly decreased disease-free survival of patients with other thyroid carcinomas.
In conclusion, the present study identified several hub genes and pathways, which will contribute to elucidating the pathogenesis of ATC and providing therapeutic targets for ATC.
American Psychological Association (APA)
Gao, Xueren& Wang, Jianguo& Zhang, Shulong. 2019. Integrated Bioinformatics Analysis of Hub Genes and Pathways in Anaplastic Thyroid Carcinomas. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1165131
Modern Language Association (MLA)
Gao, Xueren…[et al.]. Integrated Bioinformatics Analysis of Hub Genes and Pathways in Anaplastic Thyroid Carcinomas. International Journal of Endocrinology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1165131
American Medical Association (AMA)
Gao, Xueren& Wang, Jianguo& Zhang, Shulong. Integrated Bioinformatics Analysis of Hub Genes and Pathways in Anaplastic Thyroid Carcinomas. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1165131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165131