Nesprin-2 Interacts with Condensin Component SMC2
Joint Authors
Xing, Xin
Mroß, Carmen
Hao, Linlin
Herzog, Alexandra
Mohr, Clara
Unnikannan, C. P.
Kelkar, Pranav
Eichinger, Ludwig
Neumann, Sascha
Munck, Martina
Noegel, Angelika A.
Source
International Journal of Cell Biology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The nuclear envelope proteins, Nesprins, have been primarily studied during interphase where they function in maintaining nuclear shape, size, and positioning.
We analyze here the function of Nesprin-2 in chromatin interactions in interphase and dividing cells.
We characterize a region in the rod domain of Nesprin-2 that is predicted as SMC domain (aa 1436–1766).
We show that this domain can interact with itself.
It furthermore has the capacity to bind to SMC2 and SMC4, the core subunits of condensin.
The interaction was observed during all phases of the cell cycle; it was particularly strong during S phase and persisted also during mitosis.
Nesprin-2 knockdown did not affect condensin distribution; however we noticed significantly higher numbers of chromatin bridges in Nesprin-2 knockdown cells in anaphase.
Thus, Nesprin-2 may have an impact on chromosomes which might be due to its interaction with condensins or to indirect mechanisms provided by its interactions at the nuclear envelope.
American Psychological Association (APA)
Xing, Xin& Mroß, Carmen& Hao, Linlin& Munck, Martina& Herzog, Alexandra& Mohr, Clara…[et al.]. 2017. Nesprin-2 Interacts with Condensin Component SMC2. International Journal of Cell Biology،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1165151
Modern Language Association (MLA)
Xing, Xin…[et al.]. Nesprin-2 Interacts with Condensin Component SMC2. International Journal of Cell Biology No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1165151
American Medical Association (AMA)
Xing, Xin& Mroß, Carmen& Hao, Linlin& Munck, Martina& Herzog, Alexandra& Mohr, Clara…[et al.]. Nesprin-2 Interacts with Condensin Component SMC2. International Journal of Cell Biology. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1165151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165151