The Diagnostic and Prognostic Values of C-Reactive Protein and Procalcitonin during Bacterial Infections in Decompensated Cirrhosis
Joint Authors
Khedher, Sana
Fouthaili, Nasreddine
Maoui, Amira
Lahiani, Sirine
Salem, Mohamed
Bouzid, Kahena
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Bacterial infection (BI) represents the main cause of decompensation and death in cirrhotic patients.
Procalcitonin (PCT) and C-reactive protein (CRP) are two widely used biomarkers that may be helpful for early detection of BI especially in the presence of inflammation.
Their accuracy for the diagnosis of BI in patients with chronic liver disease has been a subject of debate.
In this study, we aimed to learn whether PCT and CRP would be helpful as early markers of BI in patients with cirrhosis and to evaluate their prognostic value in terms of mortality.
Subjects and Methods.
We retrospectively included 92 adult patients with decompensated cirrhosis.
PCT and CRP plasma levels were obtained within the first 24 hours of admission.
Their diagnostic and prognostic values were compared using the appropriate statistical analysis.
Results.
Ninety-two patients were included.
BI was diagnosed in 60 patients (65%).
Mean white blood cell (WBC) count (p=0.005) and PCT and CRP serum levels (p<0.001) were higher in the BI group than in the non-BI (NBI) group.
The diagnostic accuracy of CRP and PCT for the diagnosis of BI was better than that of WBC.
CRP was the most sensitive marker (70%) while PCT was the more specific (96.6%).
No one of those biomarkers was predictive of 3-month mortality in patients with BI.
Conclusion.
Regarding BI in patients with decompensated cirrhosis, CRP maintains efficiency slightly higher than that of the PCT without being discriminative.
However, no prognostic value has been established for these markers.
American Psychological Association (APA)
Khedher, Sana& Fouthaili, Nasreddine& Maoui, Amira& Lahiani, Sirine& Salem, Mohamed& Bouzid, Kahena. 2018. The Diagnostic and Prognostic Values of C-Reactive Protein and Procalcitonin during Bacterial Infections in Decompensated Cirrhosis. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1165171
Modern Language Association (MLA)
Khedher, Sana…[et al.]. The Diagnostic and Prognostic Values of C-Reactive Protein and Procalcitonin during Bacterial Infections in Decompensated Cirrhosis. Gastroenterology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1165171
American Medical Association (AMA)
Khedher, Sana& Fouthaili, Nasreddine& Maoui, Amira& Lahiani, Sirine& Salem, Mohamed& Bouzid, Kahena. The Diagnostic and Prognostic Values of C-Reactive Protein and Procalcitonin during Bacterial Infections in Decompensated Cirrhosis. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1165171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165171