High Visceral to Subcutaneous Fat Ratio Is Associated with Increased Postoperative Inflammatory Response after Colorectal Resection in Inflammatory Bowel Disease
Joint Authors
Wei, Yao
Gong, Jianfeng
Guo, Zhen
Zhu, Weiming
Zhu, Feng
Yang, Jianbo
Zhang, Tenghui
Gu, Lili
Li, Yi
Li, Ning
Li, Jieshou
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
Excessive postoperative inflammatory response, which is characterized by overproduction of cytokines, often leads to complications after colorectal surgery.
However, the impact of body composition on postoperative inflammatory response is largely unknown.
The aim of this study is to elucidate whether body fat amount and its distribution affects postoperative inflammation after colorectal surgery in IBD patients.
Methods.
Eighty-six patients undergoing colorectal resection for IBD from June 2014 to Jan 2017 were enrolled.
Abdominal CT images within one week prior to surgery were assessed for visceral fat, subcutaneous fat, and muscle mass.
Postoperative inflammatory response was evaluated using serum CRP, PCT, and IL-6 levels on postoperative days 1, 3, and 5.
Univariate analysis was conducted to identify risk factors for infectious complications.
The correlation between body composition and postoperative plasma concentration of inflammatory markers was analyzed using a linear regression model.
ROC curve was applied to analyze the effect of different body composition parameters on postoperative infectious complications and to determine the relationship between inflammatory markers and infectious complications.
Results.
Neither volume of fat or muscle was related to postoperative plasma concentrations of CRP, IL-6, and PCT.
However, visceral to subcutaneous fat ratio was associated with PCT levels on postoperative days (POD) 1, 3, and 5, with the highest regression coefficient on POD1 (β=0.360; 95% CI, 0.089–0.631; P=0.010).
Body composition did not predict postoperative infectious complications, while CRP on POD 3 was predictive of infectious complications.
Conclusion.
Increased visceral to subcutaneous fat ratio was associated with postoperative inflammatory response in IBD patients undergoing colorectal resection.
This may partly explain the increased incidence of postoperative complications in patients with visceral obesity.
American Psychological Association (APA)
Wei, Yao& Zhu, Feng& Gong, Jianfeng& Yang, Jianbo& Zhang, Tenghui& Gu, Lili…[et al.]. 2018. High Visceral to Subcutaneous Fat Ratio Is Associated with Increased Postoperative Inflammatory Response after Colorectal Resection in Inflammatory Bowel Disease. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1165241
Modern Language Association (MLA)
Wei, Yao…[et al.]. High Visceral to Subcutaneous Fat Ratio Is Associated with Increased Postoperative Inflammatory Response after Colorectal Resection in Inflammatory Bowel Disease. Gastroenterology Research and Practice No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1165241
American Medical Association (AMA)
Wei, Yao& Zhu, Feng& Gong, Jianfeng& Yang, Jianbo& Zhang, Tenghui& Gu, Lili…[et al.]. High Visceral to Subcutaneous Fat Ratio Is Associated with Increased Postoperative Inflammatory Response after Colorectal Resection in Inflammatory Bowel Disease. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1165241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165241