Efficacy of Mesoglycan in Pain Control after Excisional Hemorrhoidectomy: A Pilot Comparative Prospective Multicenter Study
Joint Authors
Gallo, Gaetano
Clerico, Giuseppe
Trompetto, Mario
Mistrangelo, Massimiliano
Passera, Roberto
Testa, Valentina
Pozzo, Mauro
Perinotti, Roberto
Lanati, Ivan
Lazzari, Ivano
Tonello, Paolo
Ugliono, Elettra
De Luca, Emilia
Realis Luc, Alberto
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Various pain management strategies for patients undergoing open excisional hemorrhoidectomy have been proposed, yet postoperative pain remains a frequent complaint.
Objective.
To determine whether mesoglycan (30 mg two vials i.m.
once/day for the first 5 days postoperative, followed by 50 mg 1 oral tablet twice/day for 30 days) would reduce the edema of the mucocutaneous bridges and thus improve postoperative pain symptoms.
Patients and Methods.
For this prospective observational multicenter study, 101 patients undergoing excisional diathermy hemorrhoidectomy for III-IV degree hemorrhoidal disease were enrolled at 5 colorectal referral centers.
Patients were assigned to receive either mesoglycan (study group SG) or a recommended oral dose of ketorolac tromethamine of 10 mg every 4–6 hours, not exceeding 40 mg per day and not exceeding 5 postoperative days according to the indications for short-term management of moderate/severe acute postoperative pain, plus stool softeners (control group CG).
Results.
Postoperative thrombosis (SG 1/48 versus CG 5/45) (p<0.001) and pain after rectal examination (p<0.001) were significantly reduced at 7–10 days after surgery in the mesoglycan-treated group, permitting a faster return to work (p<0.001); however, in the same group, the incidence of postoperative bleeding, considered relevant when needing a readmission or an unexpected outpatient visit, was higher, possibly owing to the drug’s antithrombotic properties.
Conclusions.
The administration of mesoglycan after an open diathermy excisional hemorrhoidectomy can reduce postoperative thrombosis and pain at 7–10 days after surgery, permitting a faster return to normal activities.
American Psychological Association (APA)
Gallo, Gaetano& Mistrangelo, Massimiliano& Passera, Roberto& Testa, Valentina& Pozzo, Mauro& Perinotti, Roberto…[et al.]. 2018. Efficacy of Mesoglycan in Pain Control after Excisional Hemorrhoidectomy: A Pilot Comparative Prospective Multicenter Study. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1165284
Modern Language Association (MLA)
Gallo, Gaetano…[et al.]. Efficacy of Mesoglycan in Pain Control after Excisional Hemorrhoidectomy: A Pilot Comparative Prospective Multicenter Study. Gastroenterology Research and Practice No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1165284
American Medical Association (AMA)
Gallo, Gaetano& Mistrangelo, Massimiliano& Passera, Roberto& Testa, Valentina& Pozzo, Mauro& Perinotti, Roberto…[et al.]. Efficacy of Mesoglycan in Pain Control after Excisional Hemorrhoidectomy: A Pilot Comparative Prospective Multicenter Study. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1165284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165284