Predictive Factors of Early Recurrence in Patients with Distal Cholangiocarcinoma after Pancreaticoduodenectomy
Joint Authors
Egawa, Tomohisa
Kitagawa, Yuko
Abe, Yuta
Kitago, Minoru
Itano, Osamu
Ito, Yasuhiro
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
To determine the factors associated with early recurrence in patients with distal cholangiocarcinoma after pancreaticoduodenectomy (PD).
Patients and Methods.
Sixty-one patients with distal cholangiocarcinoma were enrolled.
The clinical data and histopathological findings were collected retrospectively.
Results.
Patients were divided into two groups as follows: 16 patients (26%) with early recurrence and 45 patients (74%) with late recurrence or no recurrence.
In a univariate analysis, lymph node metastases (P=0.0016), lymphatic invasion (P<0.0001), pancreatic invasion (P=0.0006), and perineural invasion (P=0.0004) were significantly different between the two groups.
In a multivariate analysis, a higher incidence of lymphatic invasion was the only independent risk factor for early recurrence (odds ratio: 5.772, 95% confidence interval: 1.123–29.682, P=0.036).
Moreover, the disease-free survival and overall survival of patients with a higher incidence of lymphatic invasion were significantly worse compared with those of patients with a lower incidence of lymphatic invasion (P<0.001).
Conclusions.
Our study showed that a higher incidence of lymphatic invasion was a significant predictor of early recurrence in patients with distal cholangiocarcinoma.
Therefore, lymphatic invasion might be useful in determining the optimal adjuvant therapy in the early postoperative stage for distal cholangiocarcinoma.
American Psychological Association (APA)
Ito, Yasuhiro& Abe, Yuta& Egawa, Tomohisa& Kitago, Minoru& Itano, Osamu& Kitagawa, Yuko. 2018. Predictive Factors of Early Recurrence in Patients with Distal Cholangiocarcinoma after Pancreaticoduodenectomy. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1165300
Modern Language Association (MLA)
Ito, Yasuhiro…[et al.]. Predictive Factors of Early Recurrence in Patients with Distal Cholangiocarcinoma after Pancreaticoduodenectomy. Gastroenterology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1165300
American Medical Association (AMA)
Ito, Yasuhiro& Abe, Yuta& Egawa, Tomohisa& Kitago, Minoru& Itano, Osamu& Kitagawa, Yuko. Predictive Factors of Early Recurrence in Patients with Distal Cholangiocarcinoma after Pancreaticoduodenectomy. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1165300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165300