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The Characteristics, Prognosis, and Risk Factors of Lymph Node Metastasis in Early Gastric Cancer
Joint Authors
Zhang, Guoxin
Yan, Jin
Li, Xuan
Liu, Shiyu
Peng, Lei
Chen, Meihong
Yang, Jiajia
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Lymph node metastasis (LNM) is the most important risk factor for endoscopic treatment in early gastric cancer (EGC) patients.
We aimed to investigate the rate of LNM, the risk factors, and the prognosis of EGC patients with LMN.
Methods.
A total of 10,039 patients who underwent gastrectomy with lymphadenectomy were reviewed between January 2010 and December 2015 at Jiangsu Province Hospital in China.
Among them, we identified 1004 (10%) EGCs.
First, endoscopic and clinicopathological features related to LNM were analyzed, and then risk factors for LNM were identified using univariate and multivariate analysis.
Finally, the short- and long-term outcomes were compared between the groups.
Results.
LNM occurred in 123 (12.3%) EGCs.
Most of EGCs were male (n=720, 71.7%) and mean age was 59.65 ± 11.09 years.
The rate of H.
pylori infection was 78.0% (783/1004).
LNM was significantly associated with age, sex, location, lesion size, macroscopic type, depth of invasion, differentiation type, histological morphology, lymphovascular invasion (LVI), and TMN stage.
By multivariate analysis, significant independent risk factors for LNM in EGC were identified as following: male sex (OR 2.365, P=0.035), age ≦ 40 (OR 0.055, P=0.012), depressed type (OR 2.721, P=0.013), submucosa invasion (OR 2.987, P=0.032), LVI (OR 5.186, P=0.003), tumor located in corpora (OR 8.904, P=0.047), and in angle (OR 12.998, P=0.024).
86.5% were successfully followed up for 3 years.
The overall 1- and 3-year survival rates in LNM group were 100% and 91.1%, respectively, and those with no LNM were 100% and 100%, respectively.
Conclusion.
EGCs were investigated in 10.0% of gastric cancer, which LNM occurred in 12.3% of EGC.
Independent risk factors of LNM included male sex, age (>40), the depth of invasion, LVI, and tumor located in corpora or angle.
The 3-year overall survival rate was greater in EGC patients without LNM.
American Psychological Association (APA)
Li, Xuan& Liu, Shiyu& Yan, Jin& Peng, Lei& Chen, Meihong& Yang, Jiajia…[et al.]. 2018. The Characteristics, Prognosis, and Risk Factors of Lymph Node Metastasis in Early Gastric Cancer. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1165418
Modern Language Association (MLA)
Li, Xuan…[et al.]. The Characteristics, Prognosis, and Risk Factors of Lymph Node Metastasis in Early Gastric Cancer. Gastroenterology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1165418
American Medical Association (AMA)
Li, Xuan& Liu, Shiyu& Yan, Jin& Peng, Lei& Chen, Meihong& Yang, Jiajia…[et al.]. The Characteristics, Prognosis, and Risk Factors of Lymph Node Metastasis in Early Gastric Cancer. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1165418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165418