Altered Intestinal Microbiota with Increased Abundance of Prevotella Is Associated with High Risk of Diarrhea-Predominant Irritable Bowel Syndrome
Joint Authors
Chen, Shujie
Long, Yanqin
Du, Lijun
Wang, Lan
Su, Tingting
Liu, Rongbei
Lee, Allen
Lai, Sanchuan
Chen, Xueqin
Si, Jianmin
Owyang, Chung
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alterations in gut microbiota are postulated to be an etiologic factor in the pathogenesis of irritable bowel syndrome (IBS).
To determine whether IBS patients in China exhibited differences in their gut microbial composition, fecal samples were collected from diarrhea-predominant IBS (IBS-D) and healthy controls and evaluated by 16S ribosomal RNA gene sequence and quantitative real-time PCR.
A mouse model of postinfectious IBS (PI-IBS) was established to determine whether the altered gut microbiota was associated with increased visceral hypersensitivity.
The results indicated that there were significant differences in the bacterial community profiles between IBS-D patients and healthy controls.
Prevotella was more abundant in fecal samples from IBS-D patients compared with healthy controls (p<0.05).
Meanwhile, there were significant reductions in the quantity of Bacteroides, Bifidobacteria, and Lactobacillus in IBS-D patients compared with healthy controls (p<0.05).
Animal models similarly showed an increased abundance of Prevotella in fecal samples compared with control mice (p<0.05).
Finally, after the PI-IBS mice were cohoused with control mice, both the relative abundance of Prevotella and visceral hypersensitivity of PI-IBS mice were decreased.
In conclusion, the altered intestinal microbiota is associated with increased visceral hypersensitivity and enterotype enriched with Prevotella may be positively associated with high risk of IBS-D.
American Psychological Association (APA)
Su, Tingting& Liu, Rongbei& Lee, Allen& Long, Yanqin& Du, Lijun& Lai, Sanchuan…[et al.]. 2018. Altered Intestinal Microbiota with Increased Abundance of Prevotella Is Associated with High Risk of Diarrhea-Predominant Irritable Bowel Syndrome. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1165425
Modern Language Association (MLA)
Su, Tingting…[et al.]. Altered Intestinal Microbiota with Increased Abundance of Prevotella Is Associated with High Risk of Diarrhea-Predominant Irritable Bowel Syndrome. Gastroenterology Research and Practice No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1165425
American Medical Association (AMA)
Su, Tingting& Liu, Rongbei& Lee, Allen& Long, Yanqin& Du, Lijun& Lai, Sanchuan…[et al.]. Altered Intestinal Microbiota with Increased Abundance of Prevotella Is Associated with High Risk of Diarrhea-Predominant Irritable Bowel Syndrome. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1165425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165425