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Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Joint Authors
Xiong, Lingxin
Liu, Ying
Zhou, Yan
Zheng, Bingzhen
Liu, Tongjun
Xie, Wei
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
It has been found that single-nucleotide polymorphisms (SNPs) of microRNA might be involved in the development of inflammatory bowel diseases (IBDs).
However, the related retrospective research has not been reported.
In this work, we performed a meta-analysis to derive a more precise estimation of the associated relationship.
Methods.
We searched the studies on the association of SNPs of microRNA with the hereditary susceptibility of IBD in PubMed and Embase; eligible research was selected by screening the abstract and full text.
The meta-analysis was performed based on the statistical software Stata 14.0, and besides, the odds ratio and 95% confidence interval were calculated to evaluate the strength of the association.
Results.
159 papers were acquired from the PubMed and Embase databases, and five eligible articles containing nine case-control studies were selected.
In the study, we first found that the association between miRNA-196a2 rs11614913 and IBD was insignificant.
Then, the susceptibility of miRNA-146a rs2910146 to IBD increased significantly in allelic comparison, homozygote model, heterozygote model, and dominant model.
Moreover, a positive relationship between miRNA-499 rs3746444 and IBD was identified in the homozygote model.
Conclusion.
Our findings demonstrated that miRNA-146a rs2910146 (G>C) polymorphism was associated with the susceptibility to IBD and miRNA-196a2 rs11614913 (T>C) and miRNA-499 rs3746444 (A>G) did not reveal an obvious relationship with the IBD susceptibility.
American Psychological Association (APA)
Liu, Ying& Xiong, Lingxin& Zhou, Yan& Zheng, Bingzhen& Liu, Tongjun& Xie, Wei. 2018. Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1165480
Modern Language Association (MLA)
Liu, Ying…[et al.]. Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1165480
American Medical Association (AMA)
Liu, Ying& Xiong, Lingxin& Zhou, Yan& Zheng, Bingzhen& Liu, Tongjun& Xie, Wei. Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1165480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165480