Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental Implants
Joint Authors
Souza, Paulo Roberto Eleutério
Ribeiro, Rodrigo
Melo, Rayanne
Tortamano Neto, Pedro
Vajgel, André
Cimões, Renata
Source
International Journal of Dentistry
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Genetic polymorphisms in certain cytokines and chemokines have been investigated to understand why some individuals display implant flaws despite having few risk factors at the time of implant.
Purpose.
To investigate the association of genetic polymorphisms in interleukin- (IL-) 10 [-1082 region (A/G)] and RANKL [-438 region (A/G)] with the failure of dental implants.
Materials and Methods.
This study included 90 partially edentulous male and female patients who were rehabilitated with a total of 245 Straumann dental implants.
An implant was considered a failure if any of the following occurred: mobility, persistent subjective complaint, recurrent peri-implant infection with suppuration, continuous radiolucency around the implant, probing depth ≥ 5 mm, and bleeding on probing.
Buccal mucosal cells were collected for analysis of RANKL438 and IL-10.
Results.
The implant success rate in this population was 34.4%.
The mutant allele (G) in RANKL had an incidence of 52.3% and mutant allele (A) in IL-10 was observed in 37.8%.
No statistically significant difference was detected between the failure of the implant and the genotypes and allelic frequencies.
Conclusion.
No association was detected between the genetic polymorphisms of RANKL (-438) and IL-10 (-1082) and the failure of dental implants in the population studied.
American Psychological Association (APA)
Ribeiro, Rodrigo& Melo, Rayanne& Tortamano Neto, Pedro& Vajgel, André& Souza, Paulo Roberto Eleutério& Cimões, Renata. 2017. Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental Implants. International Journal of Dentistry،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1165556
Modern Language Association (MLA)
Ribeiro, Rodrigo…[et al.]. Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental Implants. International Journal of Dentistry No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1165556
American Medical Association (AMA)
Ribeiro, Rodrigo& Melo, Rayanne& Tortamano Neto, Pedro& Vajgel, André& Souza, Paulo Roberto Eleutério& Cimões, Renata. Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental Implants. International Journal of Dentistry. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1165556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165556