The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease
Joint Authors
Wu, Huangan
Liu, Huirong
Zhou, Cili
Zhao, Jimeng
Huang, Yan
Zhao, Min
Zhang, Fang
Wang, Shiyuan
Wu, Luyi
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Accumulating evidence demonstrates that microRNA- (miR-) mediated posttranscriptional regulation plays an important role in autophagy in inflammatory bowel disease (IBD), a disease that is difficult to manage clinically because of the associated chronic recurrent nonspecific inflammation.
Research indicates that microRNAs regulate autophagy via different pathways, playing an important role in the IBD process and providing a new perspective for IBD research.
Related studies have shown that miR-142-3p, miR-320, miR-192, and miR-122 target NOD2, an IBD-relevant autophagy gene, to modulate autophagy in IBD.
miR-142-3p, miR-93, miR-106B, miR-30C, miR-130a, miR-346, and miR-20a regulate autophagy by targeting ATG16L1 through several different pathways.
miR-196 can downregulate IRGM and suppress autophagy by inhibiting the accumulation of LC3II.
During the endoplasmic reticulum stress response, miR-665, miR-375, and miR-150 modulate autophagy by regulating the unfolded protein response, which may play an important role in IBD intestinal fibrosis.
Regarding autophagy-related pathways, miR-146b, miR-221-5p, miR-132, miR-223, miR-155, and miR-21 regulate NF-κB or mTOR signaling to induce or inhibit autophagy in intestinal cells by releasing anti- or proinflammatory factors, respectively.
American Psychological Association (APA)
Wang, Shiyuan& Huang, Yan& Zhou, Cili& Wu, Huangan& Zhao, Jimeng& Wu, Luyi…[et al.]. 2018. The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1165563
Modern Language Association (MLA)
Wang, Shiyuan…[et al.]. The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease. Gastroenterology Research and Practice No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1165563
American Medical Association (AMA)
Wang, Shiyuan& Huang, Yan& Zhou, Cili& Wu, Huangan& Zhao, Jimeng& Wu, Luyi…[et al.]. The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1165563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165563