Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease
Joint Authors
Sun, Weihua
Wu, Jing
Zhao, Wendi
Zhao, Shuangxia
Li, Minglong
Zhang, Xiaomei
Source
International Journal of Genomics
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study was designed to explore the association between Graves disease (GD) and thyroid-stimulating hormone receptor (TSHR) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) single nucleotide polymorphisms (SNPs).
We studied a total of 1217 subjects from a Han population in northern Anhui province in China.
Six SNPs within TSHR (rs179247, rs12101261, rs2284722, rs4903964, rs2300525, and rs17111394) and four SNPs within CTLA-4 (rs10197319, rs231726, rs231804, and rs1024161) were genotyped via a Taqman probe technique using a Fluidigm EP1 platform.
The TSHR alleles rs179247-G, rs12101261-C, and rs4903964-G were negatively correlated with GD, whereas the rs2284722-A and rs17111394-C alleles were positively correlated with GD.
Analyzing TSHR SNPs at rs179247, rs2284722, rs12101261, and rs4903964 yielded 8 different haplotypes.
There were positive correlations between GD risk and the haplotypes AGTA and AATA (OR=1.27, 95%CI=1.07‐1.50, P=0.005; OR=1.45, 95%CI=1.21‐1.75, P<0.001, respectively).
There were negative correlations between GD risk and the haplotype GGCG (OR=0.56, 95%CI=0.46‐0.67, P<0.001).
With respect to haplotypes based on SNPs at the TSHR rs2300525 and rs17111394 loci, the CC haplotype was positively correlated with GD risk (OR=1.32, 95%CI=1.08‐1.60, P=0.006).
Analyzing CTLA-4 SNPs at rs231804, rs1024161, and rs231726 yielded four haplotypes, of which AAA was positively correlated with GD risk (OR=1.21, 95%CI=1.02‐1.43, P=0.029).
Polymorphisms at rs179247, rs12101261, rs2284722, rs4903964, and rs17111394 were associated with GD susceptibility.
Haplotypes of both TSHR and CTLA-4 were additionally related to GD risk.
American Psychological Association (APA)
Sun, Weihua& Zhang, Xiaomei& Wu, Jing& Zhao, Wendi& Zhao, Shuangxia& Li, Minglong. 2019. Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease. International Journal of Genomics،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1165696
Modern Language Association (MLA)
Sun, Weihua…[et al.]. Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease. International Journal of Genomics No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1165696
American Medical Association (AMA)
Sun, Weihua& Zhang, Xiaomei& Wu, Jing& Zhao, Wendi& Zhao, Shuangxia& Li, Minglong. Correlation of TSHR and CTLA-4 Single Nucleotide Polymorphisms with Graves Disease. International Journal of Genomics. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1165696
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165696