The Short Tandem Repeat of the DMT1 Gene as a Molecular Marker of Elite Long-Distance Runners
Joint Authors
He, Zi-Hong
Yan, Xu
Wuyun, Gerile
Hu, Yang
Li, Yanchun
Source
International Journal of Genomics
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The DMT1 gene encodes divalent metal transporter 1, a membrane iron transport protein.
Divalent metal transporter 1 influences cellular iron availability, which might further affect aerobic exercise capacity.
Short tandem repeat (STR) polymorphisms have been used as genetic markers in the literature, yet the STR polymorphisms of the DMT1 gene have not been well studied.
In this current study, we explored the polymorphisms of the DMT1 gene in a group of elite long-distance runners and controls, by using the PCR-RFLP (Restriction Fragment Length Polymorphism) and Gene scan technology.
We found that the genotype frequency of the homozygous 258 bp STR polymorphism of the DMT1 gene (258 bp/258 bp) was significantly higher in the athlete group than in the controls (χ2=14.01, p=0.006) so does the allele frequency of the 258 bp STR polymorphism (χ2=12.867, p=0.008).
These data suggested that the STR polymorphism of the DMT1 gene might be correlated with aerobic exercise capacity and the 258 bp homozygous (25 bp/258 bp) could be used as a molecular marker for the talent identification of elite long-distance runners.
American Psychological Association (APA)
Wuyun, Gerile& Hu, Yang& He, Zi-Hong& Li, Yanchun& Yan, Xu. 2019. The Short Tandem Repeat of the DMT1 Gene as a Molecular Marker of Elite Long-Distance Runners. International Journal of Genomics،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1165699
Modern Language Association (MLA)
Wuyun, Gerile…[et al.]. The Short Tandem Repeat of the DMT1 Gene as a Molecular Marker of Elite Long-Distance Runners. International Journal of Genomics No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1165699
American Medical Association (AMA)
Wuyun, Gerile& Hu, Yang& He, Zi-Hong& Li, Yanchun& Yan, Xu. The Short Tandem Repeat of the DMT1 Gene as a Molecular Marker of Elite Long-Distance Runners. International Journal of Genomics. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1165699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165699