Predicting the Development of Gastric Neoplasms in a Healthcare Cohort by Combining Helicobacter pylori Antibodies and Serum Pepsinogen: A 5-Year Longitudinal Study
Joint Authors
Chung, Goh Eun
Kwak, Min-Sun
Kim, Joo Sung
Yang, Jong In
Chung, Su Jin
Kang, Seung Joo
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Helicobacter pylori (HP) and gastric atrophy are risk factors for gastric cancer.
We evaluated whether the combination of serum HP antibody and pepsinogen (PG), which is indicative of gastric atrophy, could serve as a predictive marker for the development of gastric neoplasms in a Korean population.
Methods.
The subjects who had undergone health-screening examination with endoscopic follow-ups were classified into the following 4 groups according to serum PG status and HP antibody at baseline: group A (HP (−), normal PG), group B (HP (+), normal PG), group C (HP (+), atrophic PG), and group D (HP (−), atrophic PG).
We compared the development of gastric neoplasms among the groups.
Results.
Of the 3297 subjects, 1239 (37.6%) were categorized as group A, 1484 (45.0%) as group B, 536 (16.3%) as group C, and 38 (1.2%) as group D.
During the 5.6 years of mean follow-up period, the annual incidence of gastric neoplasms increased gradually by 0.06% in group A, 0.16% in group B, 0.38% in group C, and 0.49% in group D.
A Cox proportional hazard model showed increased development of gastric neoplasms according to group (P for trend = 0.025).
Compared to group A, the hazard ratio was 8.25 for group D (95% confidence interval 0.2–74.24), 5.35 for group C (1.68–17.05), and 2.65 for group B (0.86–8.14).
Conclusion.
The combination of serum PG and HP antibody is useful for predicting the development of gastric neoplasms, including cancer and adenoma, in a Korean population using endoscopic surveillance.
American Psychological Association (APA)
Kwak, Min-Sun& Chung, Goh Eun& Chung, Su Jin& Kang, Seung Joo& Yang, Jong In& Kim, Joo Sung. 2018. Predicting the Development of Gastric Neoplasms in a Healthcare Cohort by Combining Helicobacter pylori Antibodies and Serum Pepsinogen: A 5-Year Longitudinal Study. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1165772
Modern Language Association (MLA)
Kwak, Min-Sun…[et al.]. Predicting the Development of Gastric Neoplasms in a Healthcare Cohort by Combining Helicobacter pylori Antibodies and Serum Pepsinogen: A 5-Year Longitudinal Study. Gastroenterology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1165772
American Medical Association (AMA)
Kwak, Min-Sun& Chung, Goh Eun& Chung, Su Jin& Kang, Seung Joo& Yang, Jong In& Kim, Joo Sung. Predicting the Development of Gastric Neoplasms in a Healthcare Cohort by Combining Helicobacter pylori Antibodies and Serum Pepsinogen: A 5-Year Longitudinal Study. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1165772
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165772