Pure Well-Differentiated Adenocarcinoma Is a Safe Factor for Lymph Node Metastasis in T1 and T2 Colorectal Cancer: A Pilot Study
Joint Authors
Inada, Yutaka
Otsuji, Eigo
Naito, Yuji
Yasuda, Ritsu
Murakami, Takaaki
Hirose, Ryohei
Inoue, Ken
Ogiso, Kiyoshi
Morinaga, Yukiko
Konishi, Eiichi
Arita, Tomohiro
Nakanishi, Masayoshi
Yanagisawa, Akio
Kishimoto, Mitsuo
Itoh, Yoshito
Kuriu, Yoshiaki
Yoshida, Naohisa
Murayama, Yasutoshi
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background and Aims.
Various risk factors for lymph node metastasis (LNM) have been reported in colorectal T1 cancers.
However, the factors available are insufficient for predicting LNM.
We therefore investigated the utility of the new histological factor “pure well-differentiated adenocarcinoma” (PWDA) as a safe factor for predicting LNM in T1 and T2 cancers.
Materials and Methods.
We reviewed 115 T2 cancers and 202 T1 cancers in patients who underwent surgical resection in our center.
We investigated the rates of LNM among various clinicopathological factors, including PWDA.
PWDA was defined as a lesion comprising only well-differentiated adenocarcinoma.
The consistency of the diagnosis of PWDA was evaluated among two pathologists.
In addition, 72 T1 cancers with LNM from 8 related hospitals over 10 years (2008–2017) were also analyzed.
Results.
The rates of LNM and PWDA were 23.5% and 20.0%, respectively, in T2 cancers.
Significant differences were noted between patients with and without LNM regarding lymphatic invasion (81.5% vs.
36.4%, p<0.001), poor histology (51.9% vs.
19.3%, p=0.008), and PWDA (3.7% vs.
25.0%, p=0.015).
The rates of LNM and PWDA were 8.4% and 36.1%, respectively, in T1 cancers.
Regarding the 73 PWDA cases and 129 non-PWDA cases, the rates of LNM were 0.0% and 13.2%, respectively (p<0.001).
Among the 97 cases with lymphatic or venous invasion, the rates of LNM in 29 PWDA cases and 68 non-PWDA were 0% and 14.7%, respectively (p=0.029).
The agreement of the two pathologists for the diagnosis of PWDA was acceptable (kappa value > 0.5).
A multicenter review showed no cases of PWDA among 72 T1 cancers with LNM.
Conclusions.
PWDA is considered to be a safe factor for LNM in T1 cancer.
American Psychological Association (APA)
Yoshida, Naohisa& Nakanishi, Masayoshi& Inoue, Ken& Yasuda, Ritsu& Hirose, Ryohei& Naito, Yuji…[et al.]. 2018. Pure Well-Differentiated Adenocarcinoma Is a Safe Factor for Lymph Node Metastasis in T1 and T2 Colorectal Cancer: A Pilot Study. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1165776
Modern Language Association (MLA)
Yoshida, Naohisa…[et al.]. Pure Well-Differentiated Adenocarcinoma Is a Safe Factor for Lymph Node Metastasis in T1 and T2 Colorectal Cancer: A Pilot Study. Gastroenterology Research and Practice No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1165776
American Medical Association (AMA)
Yoshida, Naohisa& Nakanishi, Masayoshi& Inoue, Ken& Yasuda, Ritsu& Hirose, Ryohei& Naito, Yuji…[et al.]. Pure Well-Differentiated Adenocarcinoma Is a Safe Factor for Lymph Node Metastasis in T1 and T2 Colorectal Cancer: A Pilot Study. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1165776
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165776