Oxidized Cell-Free DNA Is a Factor of Stress Signaling in Radiation-Induced Bystander Effects in Different Types of Human Cells

Abstract EN

In pathology or under damaging conditions, the properties of cell-free DNA (cfDNA) change.

An example of such change is GC enrichment, which drastically alters the biological properties of cfDNA.

GC-rich cfDNA is a factor of stress signaling, whereas genomic cfDNA is biologically inactive.

GC-rich cfDNA stimulates TLR9-MyD88-NF-κB signaling cascade, leading to an increase in proinflammatory cytokine levels in the organism.

In addition, GC-rich DNA is prone to oxidation and oxidized cfDNA can stimulate secondary oxidative stress.

This article is a review of works dedicated to the investigation of a low-dose ionizing radiation effect, a bystander effect, and the role of cfDNA in both of these processes.