Albumin-Bilirubin Grade as a Novel Predictor of Survival in Advanced Extrahepatic Cholangiocarcinoma
Joint Authors
Wang, Yong
Pang, Qing
Jin, Hao
Zhou, Lei
Hu, Xiaosi
Qian, Zhen
Man, Zhongran
Yang, Song
Liu, Huichun
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
Child-Pugh (CP) grade has been used to assess liver function and postoperative outcomes in biliary tract neoplasms.
The aim of this study was to preliminarily explore the prognostic significance of an alternative model of liver function, called albumin-bilirubin (ALBI) grade, in patients with extrahepatic cholangiocarcinoma (EHC).
Methods.
A total of 109 advanced EHC patients, who received percutaneous transhepatic biliary stenting combined with iodine-125 seed implantation from January 2012 to April 2017 in our department, were enrolled.
Preoperative clinical data were collected to calculate the CP and ALBI grades.
The performance of ALBI score in predicting postoperative death was compared with that of CP score by using the receiver operating characteristic (ROC) curve.
Kaplan-Meier analysis and Cox regression model were performed for overall survival (OS) analysis.
Results.
The median survival time of our cohort was 12 months, and the 1-year and 2-year survival rates were 56.9% and 12.8%, respectively.
The area under the ROC curve of ALBI score for predicting death was significantly greater than the CP score (0.751, 95% CI: 0.641–0.861, P<0.001 vs.
0.688, 95% CI: 0.567–0.809, P<0.001).
The univariate analysis revealed that the factors related to overall survival of EHC were carbohydrate antigen 19-9, total bilirubin, albumin, ALBI grade, and CP score.
In multivariate analysis, ALBI grade (HR = 1.65, 95% CI: 1.04–2.61, P=0.032), but not CP score, was identified as an independent prognostic model.
Conclusion.
We demonstrated that the ALBI grade could be used as a predictor of survival in unresectable EHC patients.
American Psychological Association (APA)
Wang, Yong& Pang, Qing& Jin, Hao& Zhou, Lei& Hu, Xiaosi& Qian, Zhen…[et al.]. 2018. Albumin-Bilirubin Grade as a Novel Predictor of Survival in Advanced Extrahepatic Cholangiocarcinoma. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1165830
Modern Language Association (MLA)
Wang, Yong…[et al.]. Albumin-Bilirubin Grade as a Novel Predictor of Survival in Advanced Extrahepatic Cholangiocarcinoma. Gastroenterology Research and Practice No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1165830
American Medical Association (AMA)
Wang, Yong& Pang, Qing& Jin, Hao& Zhou, Lei& Hu, Xiaosi& Qian, Zhen…[et al.]. Albumin-Bilirubin Grade as a Novel Predictor of Survival in Advanced Extrahepatic Cholangiocarcinoma. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1165830
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165830