Activation of Signal Transduction and Activator of Transcription 3 Signaling Contributes to Helicobacter-Associated Gastric Epithelial Proliferation and Inflammation
Joint Authors
Sue, Soichiro
Maeda, Shin
Sasaki, Tomohiko
Kaneko, Hiroaki
Kondo, Masaaki
Ishii, Yasuaki
Sato, Takeshi
Irie, Kuniyasu
Sugimori, Makoto
Kaneta, Yoshihiro
Kanno, Masatomo
Kameta, Eri
Shibata, Wataru
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background/Aim.
Although IL-6-mediated activation of the signal transduction and activator of transcription 3 (STAT3) axis is involved in inflammation and cancer, the role of STAT3 in Helicobacter-associated gastric inflammation and carcinogenesis is unclear.
This study investigated the role of STAT3 in gastric inflammation and carcinogenesis and examined the molecular mechanism of Helicobacter-induced gastric phenotypes.
Methods.
To evaluate the contribution of STAT3 to gastric inflammation and carcinogenesis, we used wild-type (WT) and gastric epithelial conditional Stat3-knockout (Stat3Δgec) mice.
Mice were infected with Helicobacter felis and euthanized at 18 months postinfection.
Mouse gastric organoids were treated with recombinant IL-6 (rIL-6) or rIL-11 and a JAK inhibitor (JAKi) to assess the role of IL-6/STAT3 signaling in vitro.
Results.
Inflammation and mucous metaplasia were more severe in WT mice than in Stat3Δgec mice.
The epithelial cell proliferation rate and STAT3 activation were increased in WT mice.
Application of rIL-6 and rIL-11 induced expression of intestinal metaplasia-associated genes, such as Tff2; this induction was suppressed by JAKi administration.
Conclusions.
Loss of STAT3 signaling in the gastric mucosa leads to decreased epithelial cell proliferation, atrophy, and metaplasia in the setting of Helicobacter infection.
Therefore, activation of STAT3 signaling may play a key role in Helicobacter-associated gastric carcinogenesis.
American Psychological Association (APA)
Ishii, Yasuaki& Shibata, Wataru& Sugimori, Makoto& Kaneta, Yoshihiro& Kanno, Masatomo& Sato, Takeshi…[et al.]. 2018. Activation of Signal Transduction and Activator of Transcription 3 Signaling Contributes to Helicobacter-Associated Gastric Epithelial Proliferation and Inflammation. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1165898
Modern Language Association (MLA)
Ishii, Yasuaki…[et al.]. Activation of Signal Transduction and Activator of Transcription 3 Signaling Contributes to Helicobacter-Associated Gastric Epithelial Proliferation and Inflammation. Gastroenterology Research and Practice No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1165898
American Medical Association (AMA)
Ishii, Yasuaki& Shibata, Wataru& Sugimori, Makoto& Kaneta, Yoshihiro& Kanno, Masatomo& Sato, Takeshi…[et al.]. Activation of Signal Transduction and Activator of Transcription 3 Signaling Contributes to Helicobacter-Associated Gastric Epithelial Proliferation and Inflammation. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1165898
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165898