Mesenchymal Stem Cell Transplantation for Liver Cell Failure: A New Direction and Option
Joint Authors
Lin, Rong
Cao, Yantian
Zhang, Bangjie
Wang, Qingzhi
Wang, Jie
Shen, Fangfang
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background and Aims.
Mesenchymal stem cell transplantation (MSCT) became available with liver failure (LF), while the advantages of MSCs remain controversial.
We aimed to assess clinical advantages of MSCT in patients with LF.
Methods.
Clinical researches reporting MSCT in LF patients were searched and included.
Results.
Nine articles (n=476) related with LF patients were enrolled.
After MSCT, alanine aminotransferase (ALT) baseline decreased largely at half a month (P<0.05); total bilirubin (TBIL) baseline declined to a certain stable level of 78.57 μmol/L at 2 and 3 months (P<0.05).
Notably, the decreased value (D value) of Model for End-Stage Liver Disease score (MELD) of acute-on-chronic liver failure (ACLF) group was higher than that of chronic liver failure (CLF) group (14.93 ± 1.24 versus 4.6 ± 5.66, P<0.05).
Moreover, MELD baseline of ≥20 group was a higher D value of MELD than MELD baseline of <20 group with a significant statistical difference after MSCT (P=0.003).
Conclusion.
The early assessment of the efficacy of MSCT could be based on variations of ALT at half a month and TBIL at 2 and 3 months.
And it had beneficial effects for patients with LF, especially in ACLF based on the D value of MELD.
American Psychological Association (APA)
Cao, Yantian& Zhang, Bangjie& Lin, Rong& Wang, Qingzhi& Wang, Jie& Shen, Fangfang. 2018. Mesenchymal Stem Cell Transplantation for Liver Cell Failure: A New Direction and Option. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1165919
Modern Language Association (MLA)
Cao, Yantian…[et al.]. Mesenchymal Stem Cell Transplantation for Liver Cell Failure: A New Direction and Option. Gastroenterology Research and Practice No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1165919
American Medical Association (AMA)
Cao, Yantian& Zhang, Bangjie& Lin, Rong& Wang, Qingzhi& Wang, Jie& Shen, Fangfang. Mesenchymal Stem Cell Transplantation for Liver Cell Failure: A New Direction and Option. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1165919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165919