A New Murine Model of Chronic Kidney Disease-Mineral and Bone Disorder
Joint Authors
Fahrleitner-Pammer, Astrid
Frauscher, Bianca
Artinger, Katharina
Kirsch, Alexander H.
Aringer, Ida
Moschovaki-Filippidou, Foteini
Kétszeri, Máté
Schabhüttl, Corinna
Rainer, Peter P.
Schmidt, Albrecht
Stojakovic, Tatjana
Rosenkranz, Alexander R.
Eller, Philipp
Eller, Kathrin
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Chronic kidney disease (CKD) is associated with mineral and bone disorder (MBD), which is the main cause of the extensively increased cardiovascular mortality in the CKD population.
We now aimed to establish a new murine experimental CKD-MBD model.
Dilute brown non-Agouti (DBA/2) mice were fed with high-phosphate diet for 4 (HPD4) or 7 (HPD7) days, then with standard chow diet (SCD) and subsequently followed until day 84.
They were compared to DBA/2 mice maintained on SCD during the whole study period.
Both 4 and 7 days HPD-fed mice developed phosphate nephropathy with tubular atrophy, interstitial fibrosis, decreased glomerular filtration rate, and increased serum urea levels.
The abdominal aorta of HPD-treated mice showed signs of media calcification.
Histomorphometric analysis of HPD-treated mice showed decreased bone volume/tissue volume, low mineral apposition rate, and low bone formation rate as compared to SCD-fed mice, despite increased parathyroid hormone levels.
Overall, the observed phenotype was more pronounced in the HPD7 group.
In summary, we established a new, noninvasive, and therefore easy to perform reproducible CKD-MBD model, which showed media calcification, secondary hyperparathyroidism, and low-turnover bone disease.
American Psychological Association (APA)
Frauscher, Bianca& Artinger, Katharina& Kirsch, Alexander H.& Aringer, Ida& Moschovaki-Filippidou, Foteini& Kétszeri, Máté…[et al.]. 2017. A New Murine Model of Chronic Kidney Disease-Mineral and Bone Disorder. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1165998
Modern Language Association (MLA)
Frauscher, Bianca…[et al.]. A New Murine Model of Chronic Kidney Disease-Mineral and Bone Disorder. International Journal of Endocrinology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1165998
American Medical Association (AMA)
Frauscher, Bianca& Artinger, Katharina& Kirsch, Alexander H.& Aringer, Ida& Moschovaki-Filippidou, Foteini& Kétszeri, Máté…[et al.]. A New Murine Model of Chronic Kidney Disease-Mineral and Bone Disorder. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1165998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165998