Diclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Murine Model of Acute Pancreatitis Induced by Caerulein
Joint Authors
Ozer Cakir, Ozlem
Findik, Siddika
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
We determined the effects of diclofenac sodium, octreotide, and their combination on extrapancreatic organ injuries in caerulein-induced acute pancreatitis in mice.
Methods.
A total of 58 BALB-C male mice (25 g) were divided into seven groups and used to create a caerulein-induced acute pancreatitis model.
Diclofenac sodium, octreotide, and their combination were given for treatment of caerulin-induced acute pancreatitis in mice.
At the end of the experiment, the lung, liver, kidney, and stomach were removed for histopathologic assessment.
Results.
Histopathologic investigation revealed a statistically significant difference between the groups in mean congestion, edema, tubular injury, perirenal fat tissue inflammation, and tubular stasis scores in kidney tissue (P<0.001, P<0.001, P<0.001, P<0.001, and P=0.048, respectively); mean congestion, edema, neutrophil inflammation, mononuclear inflammation, and emphysematous change scores in the lung (P<0.001, P<0.001, P<0.001, P=0.030, and P<0.001, respectively); mean congestion, edema, and neutrophil inflammation scores in the stomach (P=0.008, P=0.014, and P<0.001, respectively); and mean congestion and hydropic degeneration scores in the liver (P=0.029 and P=0.002, respectively).
Conclusion.
Diclofenac sodium alone ameliorates lung edema due to caerulin-induced acute pancreatitis.
American Psychological Association (APA)
Ozer Cakir, Ozlem& Findik, Siddika. 2018. Diclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Murine Model of Acute Pancreatitis Induced by Caerulein. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1166033
Modern Language Association (MLA)
Ozer Cakir, Ozlem& Findik, Siddika. Diclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Murine Model of Acute Pancreatitis Induced by Caerulein. Gastroenterology Research and Practice No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1166033
American Medical Association (AMA)
Ozer Cakir, Ozlem& Findik, Siddika. Diclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Murine Model of Acute Pancreatitis Induced by Caerulein. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1166033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166033