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Benzoyl Peroxide Inhibits Quorum Sensing and Biofilm Formation by Gardnerella vaginalis 14018
Joint Authors
Zehm, Saskia
Netrebov, Victoria
Weeks, Richard
Algburi, Ammar
Zubovskiy, Konstantin
Chikindas, Michael L.
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Infection recurrence and antibiotic resistance of bacterial vaginosis-associated pathogenic biofilms underline the need for novel and effective treatment strategies.
In this study, we evaluated the antimicrobial, antibiofilm, and quorum sensing inhibitory effects of benzoyl peroxide and salicylic acid against Gardnerella vaginalis ATCC 14018, the predominant pathogen of bacterial vaginosis.
While the highest tested concentrations of 250 and 125 μg/mL for both compounds were not sufficient in completely inhibiting the growth of G.
vaginalis ATCC 14018, they did prevent biofilm formation by inhibiting the bacterial quorum sensing system in the pathogen.
To our knowledge, this report is the first evidence that benzoyl peroxide can have a quorum sensing-mediated biofilm controlling effect, as demonstrated using subinhibitory concentrations of this compound in order to reduce the cost, dosage, and negative side effects associated with current antimicrobial treatments.
American Psychological Association (APA)
Algburi, Ammar& Zehm, Saskia& Netrebov, Victoria& Weeks, Richard& Zubovskiy, Konstantin& Chikindas, Michael L.. 2018. Benzoyl Peroxide Inhibits Quorum Sensing and Biofilm Formation by Gardnerella vaginalis 14018. Infectious Diseases in Obstetrics and Gynecology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1166054
Modern Language Association (MLA)
Algburi, Ammar…[et al.]. Benzoyl Peroxide Inhibits Quorum Sensing and Biofilm Formation by Gardnerella vaginalis 14018. Infectious Diseases in Obstetrics and Gynecology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1166054
American Medical Association (AMA)
Algburi, Ammar& Zehm, Saskia& Netrebov, Victoria& Weeks, Richard& Zubovskiy, Konstantin& Chikindas, Michael L.. Benzoyl Peroxide Inhibits Quorum Sensing and Biofilm Formation by Gardnerella vaginalis 14018. Infectious Diseases in Obstetrics and Gynecology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1166054
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166054