Chronic NO Restriction in Hypertensive Rats Increases Abdominal but Not Thoracic Aortic Intrinsic Stiffness via an Augmentation in Profibrotic Materials
Joint Authors
Lindesay, George
Bézie, Yvonnick
Ragonnet, Christophe
Duchatelle, Véronique
Isabelle, Marc
Villeneuve, Nicole
Vayssettes-Courchay, Christine
Source
International Journal of Hypertension
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The spontaneously hypertensive rat model with reduced NO synthesis (SHRLN) shares features with aging and hypertension in humans, among other a severe aortic stiffening.
The present in vivo study aimed to compare thoracic (TA) and abdominal (AA) aortic stiffness in the SHRLN (treated 5 weeks with L-NAME), SHR, and normotensive Wistar Kyoto (WKY).
Dynamic properties of TA and AA were measured in the same rats, using echotracking recording of aortic diameter coupled with blood pressure (BP).
Measurements were performed first at operating BP and then after BP reduction in hypertensive rats, thus in isobaric conditions.
Histological staining and immunohistochemistry were used for structural analysis at both sites.
At operating pressure, BP and pulse pressure (PP) were higher in SHRLN compared with SHR.
Stiffness index was also increased and distensibility decreased in both TA and AA in SHRLN.
At WKY-matched blood pressure, isobaric AA parameters remained specifically altered in SHRLN, whereas TA recovered to values identical to WKYs.
Collagen, fibronectin, α5-selectin, and FAK were increased in SHRLN compared with SHR or WKY.
Nevertheless, only the strong accumulations of fibronectin and collagen at the AA site in SHRLN were associated with intrinsic stiffening.
In conclusion, we confirm that NO restriction associated with hypertension induces a severe pathological phenotype and shows that L-NAME induced stiffening is more pronounced in AA than in TA as a result of greater fibrosis.
American Psychological Association (APA)
Lindesay, George& Bézie, Yvonnick& Ragonnet, Christophe& Duchatelle, Véronique& Isabelle, Marc& Villeneuve, Nicole…[et al.]. 2019. Chronic NO Restriction in Hypertensive Rats Increases Abdominal but Not Thoracic Aortic Intrinsic Stiffness via an Augmentation in Profibrotic Materials. International Journal of Hypertension،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1166062
Modern Language Association (MLA)
Lindesay, George…[et al.]. Chronic NO Restriction in Hypertensive Rats Increases Abdominal but Not Thoracic Aortic Intrinsic Stiffness via an Augmentation in Profibrotic Materials. International Journal of Hypertension No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1166062
American Medical Association (AMA)
Lindesay, George& Bézie, Yvonnick& Ragonnet, Christophe& Duchatelle, Véronique& Isabelle, Marc& Villeneuve, Nicole…[et al.]. Chronic NO Restriction in Hypertensive Rats Increases Abdominal but Not Thoracic Aortic Intrinsic Stiffness via an Augmentation in Profibrotic Materials. International Journal of Hypertension. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1166062
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166062