Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients
Joint Authors
Liu, Xin
Zhang, Dongxue
Wei, Bojun
Qiao, Guoliang
Jiang, Tao
Chen, Zhenwen
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Long noncoding RNAs (lncRNAs) were recently shown to have potential in the diagnosis and prognosis for numerous cancers.
lncRNA GAS8-AS1 is decreased in papillary thyroid cancer (PTC) tissue, but its plasma expression and clinical value in patients with PTC remain unknown.
Materials and Methods.
We investigated the expression profile of plasma GAS8-AS1 in 97 patients with PTC and 39 patients with nodular goiter by quantitative real-time polymerase chain reaction.
Results.
GAS8-AS1 expression in plasma was downregulated in patients with PTC in comparison with those in nodular goiters (P<0.001).
A low level of plasma GAS8-AS1 expression was correlated with lymph node metastasis (LNM) (P<0.001).
Multivariate analysis showed that a reduced GAS8-AS1 level in plasma was associated with LNM (P<0.05).
The area under the receiver operating characteristic curve for GAS8-AS1 was 0.746 in LNM prediction (P<0.001).
Conclusion.
The present study indicates that circulating GAS8-AS1 is a potential biomarker for PTC diagnosis and LNM prediction.
American Psychological Association (APA)
Zhang, Dongxue& Liu, Xin& Wei, Bojun& Qiao, Guoliang& Jiang, Tao& Chen, Zhenwen. 2017. Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1166065
Modern Language Association (MLA)
Zhang, Dongxue…[et al.]. Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients. International Journal of Endocrinology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1166065
American Medical Association (AMA)
Zhang, Dongxue& Liu, Xin& Wei, Bojun& Qiao, Guoliang& Jiang, Tao& Chen, Zhenwen. Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1166065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166065