Circulatory Immune Cells in Cushing Syndrome: Bystanders or Active Contributors to Atherometabolic Injury? A Study of Adhesion and Activation of Cell Surface Markers
Joint Authors
Aranda, Gloria
Lopez, Cristina
Fernandez-Ruiz, Rebeca
Esteban, Yaiza
Garcia-Eguren, Guillermo
Mora, Mireia
Halperin, Irene
Casals, Gregori
Hanzu, Felicia A.
Enseñat, Joaquim
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Glucocorticoids (GC) induce cardiometabolic risk while atherosclerosis is a chronic inflammation involving immunity.
GC are immune suppressors, and the adrenocorticotrophic hormone (ACTH) has immune modulator activities.
Both may act in atherothrombotic inflammation involving immune cells (IMNC).
Aim.
To investigate adhesion and activation surface cell markers (CDs) of peripheral IMNC in endogenous Cushing syndrome (CS) and the immune modulator role of ACTH.
Material and Methods.
16 ACTH-dependent CS (ACTH-D), 10 ACTH-independent (ACTH-ID) CS, and 16 healthy controls (C) were included.
Leukocytes (Leuc), monocytes (MN), lymphocytes (Lym), and neutrophils (N) were analyzed by flow cytometry for atherosclerosis previously associated with CDs.
Results.
Leuc, N, and MN correlated with CS (p<0.05), WC (p<0.001), WHR (p=0.003), BMI (p<0.001), and hs-CRP (p<0.001).
CD14++CD16+ (p=0.047); CD14+CD16++ (p=0.053) MN; CD15+ (p=0.027); CD15+CD16+ (p=0.008) N; and NK-Lym (p=0.019) were higher in CS.
CD14+CD16++ MN were higher in ACTH-ID (8.9 ± 3.5%) versus ACTH-D CS (4.2 ± 1.9%) versus C (4.9 ± 2.3%).
NK-Lym correlated with c-LDL (r = 0.433, p=0.039) and CD15+ N with hs-CRP (r = 0.446, p=0.037).
In multivariate analysis, Leuc, N, and MN depended on BMI (p=0.021), WC (p=0.002), and WHR (p=0.014), while CD15+ and CD15+CD16+ N on hypercortisolism and CS (p=0.035).
Conclusion.
In CS, IMNC present changes in activation and adhesion CDs implicated in atherothrombotic inflammation.
ACTH-IDCS presents a particular IMNC phenotype, possibly due to the absence of the immune modulator effect of ACTH.
American Psychological Association (APA)
Aranda, Gloria& Lopez, Cristina& Fernandez-Ruiz, Rebeca& Esteban, Yaiza& Garcia-Eguren, Guillermo& Mora, Mireia…[et al.]. 2017. Circulatory Immune Cells in Cushing Syndrome: Bystanders or Active Contributors to Atherometabolic Injury? A Study of Adhesion and Activation of Cell Surface Markers. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166082
Modern Language Association (MLA)
Aranda, Gloria…[et al.]. Circulatory Immune Cells in Cushing Syndrome: Bystanders or Active Contributors to Atherometabolic Injury? A Study of Adhesion and Activation of Cell Surface Markers. International Journal of Endocrinology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1166082
American Medical Association (AMA)
Aranda, Gloria& Lopez, Cristina& Fernandez-Ruiz, Rebeca& Esteban, Yaiza& Garcia-Eguren, Guillermo& Mora, Mireia…[et al.]. Circulatory Immune Cells in Cushing Syndrome: Bystanders or Active Contributors to Atherometabolic Injury? A Study of Adhesion and Activation of Cell Surface Markers. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166082
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166082