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Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue
Joint Authors
Lizcano, Fernando
Vargas, Diana
Camacho, Jaime
Duque, Juan
Carreño, Marisol
Acero, Edward
Pérez, Máximo
Ramirez, Sergio
Umaña, Juan
Obando, Carlos
Guerrero, Albert
Sandoval, Néstor
Rodríguez, Gina
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Adipose tissue can affect the metabolic control of the cardiovascular system, and its anatomic location can affect the vascular function differently.
In this study, biochemical and phenotypical characteristics of adipose tissue from periaortic fat were evaluated.
Periaortic and subcutaneous adipose tissues were obtained from areas surrounding the ascending aorta and sternotomy incision, respectively.
Adipose tissues were collected from patients undergoing myocardial revascularization or mitral valve replacement surgery.
Morphological studies with hematoxylin/eosin and immunohistochemical assay were performed in situ to quantify adipokine expression.
To analyze adipogenic capacity, adipokine expression, and the levels of thermogenic proteins, adipocyte precursor cells were isolated from periaortic and subcutaneous adipose tissues and induced to differentiation.
The precursors of adipocytes from the periaortic tissue accumulated less triglycerides than those from the subcutaneous tissue after differentiation and were smaller than those from subcutaneous adipose tissue.
The levels of proteins involved in thermogenesis and energy expenditure increased significantly in periaortic adipose tissue.
Additionally, the expression levels of adipokines that affect carbohydrate metabolism, such as FGF21, increased significantly in mature adipocytes induced from periaortic adipose tissue.
These results demonstrate that precursors of periaortic adipose tissue in humans may affect cardiovascular events and might serve as a target for preventing vascular diseases.
American Psychological Association (APA)
Vargas, Diana& Camacho, Jaime& Duque, Juan& Carreño, Marisol& Acero, Edward& Pérez, Máximo…[et al.]. 2017. Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166087
Modern Language Association (MLA)
Vargas, Diana…[et al.]. Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue. International Journal of Endocrinology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1166087
American Medical Association (AMA)
Vargas, Diana& Camacho, Jaime& Duque, Juan& Carreño, Marisol& Acero, Edward& Pérez, Máximo…[et al.]. Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166087