Periodontal Disease, Inflammatory Cytokines, and PGE2 in Pregnant Patients at Risk of Preterm Delivery: A Pilot Study
Joint Authors
Latorre Uriza, Catalina
Velosa-Porras, Juliana
Roa, Nelly S.
Quiñones Lara, Stephani Margarita
Silva, Jaime
Ruiz, Alvaro J.
Escobar Arregoces, Francina Maria
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Periodontal disease is an infection that, in pregnant women, can act as a risk factor for preterm delivery by increasing local and systemic inflammatory responses.
Objective.
To analyze the presence of periodontal disease, proinflammatory cytokines, and prostaglandin E 2 (PGE2) in pregnant patients at high risk for preterm delivery.
Materials and Methods.
Pilot study for a case-control study.
We included 46 pregnant patients (23 patients at risk of preterm delivery as cases and 23 patients without risk of preterm delivery as controls).
We excluded patients who received periodontal treatment, antibiotics, or antimicrobials over the last 3 months as well as those with infections or diseases such as diabetes or hypercholesterolemia.
The patients underwent a periodontal assessment, and their levels of cytokines (interleukin- [IL-] 2, IL-6, IL-10, and tumor necrosis factor- [TNF-] α) and prostaglandin E2 (PGE2) were quantified.
Results.
Patients with periodontal disease showed higher levels of cytokines (IL-2, IL-6, IL-10, and TNF-α) and PGE 2.
Patients at high risk for preterm birth showed higher IL levels compared with patients at low risk for preterm delivery.
PGE 2 increased with the severity of periodontal disease.
PGE 2 was higher in patients at low risk for preterm delivery, although this difference was not significant.
Conclusion.
Periodontal disease can increase the systemic inflammatory response as well as the levels of PGE 2 and inflammatory cytokines in pregnant patients.
American Psychological Association (APA)
Latorre Uriza, Catalina& Velosa-Porras, Juliana& Roa, Nelly S.& Quiñones Lara, Stephani Margarita& Silva, Jaime& Ruiz, Alvaro J.…[et al.]. 2018. Periodontal Disease, Inflammatory Cytokines, and PGE2 in Pregnant Patients at Risk of Preterm Delivery: A Pilot Study. Infectious Diseases in Obstetrics and Gynecology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1166088
Modern Language Association (MLA)
Latorre Uriza, Catalina…[et al.]. Periodontal Disease, Inflammatory Cytokines, and PGE2 in Pregnant Patients at Risk of Preterm Delivery: A Pilot Study. Infectious Diseases in Obstetrics and Gynecology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1166088
American Medical Association (AMA)
Latorre Uriza, Catalina& Velosa-Porras, Juliana& Roa, Nelly S.& Quiñones Lara, Stephani Margarita& Silva, Jaime& Ruiz, Alvaro J.…[et al.]. Periodontal Disease, Inflammatory Cytokines, and PGE2 in Pregnant Patients at Risk of Preterm Delivery: A Pilot Study. Infectious Diseases in Obstetrics and Gynecology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1166088
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166088