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Importance of High-Risk Human Papillomavirus Infection Detection in Female Renal Transplant Recipients in the First Year after Transplantation
Joint Authors
Chapenko, Svetlana
Cistjakovs, Maksims
Sultanova, Alina
Jermakova, Olga
Sokolovska, Liba
Lesina-Korne, Baiba
Rozental, Rafail
Murovska, Modra
Ziedina, Ieva
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
Most of human papillomavirus (HPV) infections are “cleared” by the immune system; however, in cases of immune system suppression, infections could lead to development of malignancies.
The aim of this study was to find out the frequency of HR-HPV infection in early period after renal transplantation in recipients receiving immunosuppressive therapy and to follow the progression of the infection up to one year.
Methods.
43 female renal transplant recipients and 79 healthy female individuals as a control group were enrolled in this investigation.
For the detection of HPV infection, patients’ samples (blood and vaginal swabs) were collected two weeks after transplantation with following collection of six months and one year.
Different polymerase chain reactions for HR-HPV genomic sequences detection and ELISA kit for detection of anti-HPV IgG antibodies were used.
Results.
In this study, we show that frequency rate of HR-HPV infection has increased in the first year after transplantation from early stage of immunosuppressive therapy (from 24% to 36%).
Also an increase of HR-HPV load was detected over time, showing the highest median viral load at sixth month after transplantation.
Conclusions.
From the obtained data, it follows that it is very important to carefully monitor patients receiving immunosuppression therapy on progression of HR-HPV.
American Psychological Association (APA)
Cistjakovs, Maksims& Sultanova, Alina& Jermakova, Olga& Sokolovska, Liba& Chapenko, Svetlana& Lesina-Korne, Baiba…[et al.]. 2018. Importance of High-Risk Human Papillomavirus Infection Detection in Female Renal Transplant Recipients in the First Year after Transplantation. Infectious Diseases in Obstetrics and Gynecology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1166100
Modern Language Association (MLA)
Cistjakovs, Maksims…[et al.]. Importance of High-Risk Human Papillomavirus Infection Detection in Female Renal Transplant Recipients in the First Year after Transplantation. Infectious Diseases in Obstetrics and Gynecology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1166100
American Medical Association (AMA)
Cistjakovs, Maksims& Sultanova, Alina& Jermakova, Olga& Sokolovska, Liba& Chapenko, Svetlana& Lesina-Korne, Baiba…[et al.]. Importance of High-Risk Human Papillomavirus Infection Detection in Female Renal Transplant Recipients in the First Year after Transplantation. Infectious Diseases in Obstetrics and Gynecology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1166100
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166100