Antithyroid Drug Therapy for Graves’ Disease and Implications for Recurrence
Joint Authors
Liu, Jia
Wang, Guang
Fu, Jing
Xu, Yuan
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Graves’ disease (GD) is the most common cause of hyperthyroidism worldwide.
Current therapeutic options for GD include antithyroid drugs (ATD), radioactive iodine, and thyroidectomy.
ATD treatment is generally well accepted by patients and clinicians due to some advantages including normalizing thyroid function in a short time, hardly causing hypothyroidism, and ameliorating immune disorder while avoiding radiation exposure and invasive procedures.
However, the relatively high recurrence rate is a major concern for ATD treatment, which is associated with multiple influencing factors like clinical characteristics, treatment strategies, and genetic and environmental factors.
Of these influencing factors, some are modifiable but some are nonmodifiable.
The recurrence risk can be reduced by adjusting the modifiable factors as much as possible.
The titration regimen for 12–18 months is the optimal strategy of ATD.
Levothyroxine administration after successful ATD treatment was not recommended.
The addition of immunosuppressive drugs might be helpful to decrease the recurrence rate of GD patients after ATD withdrawal, whereas further studies are needed to address the safety and efficacy.
This paper reviewed the current knowledge of ATD treatment and mainly focused on influencing factors for recurrence in GD patients with ATD treatment.
American Psychological Association (APA)
Liu, Jia& Fu, Jing& Xu, Yuan& Wang, Guang. 2017. Antithyroid Drug Therapy for Graves’ Disease and Implications for Recurrence. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166162
Modern Language Association (MLA)
Liu, Jia…[et al.]. Antithyroid Drug Therapy for Graves’ Disease and Implications for Recurrence. International Journal of Endocrinology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1166162
American Medical Association (AMA)
Liu, Jia& Fu, Jing& Xu, Yuan& Wang, Guang. Antithyroid Drug Therapy for Graves’ Disease and Implications for Recurrence. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166162