The Association between Bone Quality and Atherosclerosis: Results from Two Large Population-Based Studies
Joint Authors
Dörr, Marcus
Lange, V.
Schminke, U.
Völzke, H.
Wallaschofski, H.
Hannemann, A.
Nauck, Matthias
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
It is highly debated whether associations between osteoporosis and atherosclerosis are independent of cardiovascular risk factors.
We aimed to explore the associations between quantitative ultrasound (QUS) parameters at the heel with the carotid artery intima-media thickness (IMT), the presence of carotid artery plaques, and the ankle-brachial index (ABI).
Methods.
The study population comprised 5680 men and women aged 20–93 years from two population-based cohort studies: Study of Health in Pomerania (SHIP) and SHIP-Trend.
QUS measurements were performed at the heel.
The extracranial carotid arteries were examined with B-mode ultrasonography.
ABI was measured in a subgroup of 3853 participants.
Analyses of variance and linear and logistic regression models were calculated and adjusted for major cardiovascular risk factors.
Results.
Men but not women had significantly increased odds for carotid artery plaques with decreasing QUS parameters independent of diabetes mellitus, dyslipidemia, and hypertension.
Beyond this, the QUS parameters were not significantly associated with IMT or ABI in fully adjusted models.
Conclusions.
Our data argue against an independent role of bone metabolism in atherosclerotic changes in women.
Yet, in men, associations with advanced atherosclerosis, exist.
Thus, men presenting with clinical signs of osteoporosis may be at increased risk for atherosclerotic disease.
American Psychological Association (APA)
Lange, V.& Dörr, Marcus& Schminke, U.& Völzke, H.& Nauck, Matthias& Wallaschofski, H.…[et al.]. 2017. The Association between Bone Quality and Atherosclerosis: Results from Two Large Population-Based Studies. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166176
Modern Language Association (MLA)
Lange, V.…[et al.]. The Association between Bone Quality and Atherosclerosis: Results from Two Large Population-Based Studies. International Journal of Endocrinology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1166176
American Medical Association (AMA)
Lange, V.& Dörr, Marcus& Schminke, U.& Völzke, H.& Nauck, Matthias& Wallaschofski, H.…[et al.]. The Association between Bone Quality and Atherosclerosis: Results from Two Large Population-Based Studies. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166176