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Angiotensin-Converting Enzyme Inhibition and Parathyroid Hormone Secretion
Joint Authors
Connors, Molly
Vaidya, Anand
Zaheer, Sarah
Brown, Jenifer M.
Williams, Jonathan S.
Adler, Gail K.
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Prior studies suggest that renin-angiotensin-aldosterone system (RAAS) inhibitors decrease parathyroid hormone (PTH) secretion.
Objective.
To evaluate the effect of angiotensin-converting enzyme inhibitors (ACEi) on serum PTH in participants with and without primary hyperparathyroidism (P-HPT).
Methods.
An open-label, single-arm, pilot study whereby participants with and without P-HPT had PTH were evaluated before and after 1 week of maximally tolerated lisinopril therapy.
Results.
A total of 12 participants with, and 15 participants without, P-HPT successfully completed the protocol.
Following 1 week of lisinopril, participants with P-HPT had a decrease in systolic blood pressure (SBP) (−6.4 mmHg, P<0.01), an increase in plasma renin activity (PRA) (+1.50 ng/mL/h, P=0.06), and a decrease in PTH (79.5 (21.6) to 70.9 (19.6) pg/mL, ∆=−8.6 pg/mL, P=0.049); however, serum and urine calcium did not change.
In contrast, although 1 week of lisinopril significantly decreased SBP and increased PRA among participants without P-HPT, there were no changes in PTH or calcium.
Conclusion.
In this short pilot investigation, 1 week of maximally titrated ACEi did not impact PTH in participants without P-HPT, but resulted in a modest and marginally significant reduction of PTH but not calcium, among participants with P-HPT.
This trial is registered with ClinicalTrials.gov NCT01691781.
American Psychological Association (APA)
Zaheer, Sarah& Brown, Jenifer M.& Connors, Molly& Williams, Jonathan S.& Adler, Gail K.& Vaidya, Anand. 2017. Angiotensin-Converting Enzyme Inhibition and Parathyroid Hormone Secretion. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166191
Modern Language Association (MLA)
Zaheer, Sarah…[et al.]. Angiotensin-Converting Enzyme Inhibition and Parathyroid Hormone Secretion. International Journal of Endocrinology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1166191
American Medical Association (AMA)
Zaheer, Sarah& Brown, Jenifer M.& Connors, Molly& Williams, Jonathan S.& Adler, Gail K.& Vaidya, Anand. Angiotensin-Converting Enzyme Inhibition and Parathyroid Hormone Secretion. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166191