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Muscarinic Receptors Types 1 and 2 in the Preoptic-Anterior Hypothalamic Areas Regulate Ovulation Unequally in the Rat Oestrous Cycle
Joint Authors
López-Ramírez, Yadira L.
López-Ramírez, Kayro
Arrieta-Cruz, Isabel
Flores, Angélica
Mendoza-Garcés, Luciano
Librado-Osorio, Raúl A.
Gutiérrez-Juárez, Roger
Domínguez, Roberto
Cruz, María Esther
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Muscarinic receptors types 1 (m1AChR) and 2 (m2AChR) in the preoptic and anterior hypothalamus areas (POA-AHA) were counted, and the effects of blocking these receptors on spontaneous ovulation were analysed throughout the rat oestrous cycle.
Rats in each phase of the oestrous cycle were assigned to the following experiments: (1) an immunohistochemical study of the number of cells expressing m1AChR or m2AChR in the POA-AHA and (2) analysis of the effects of the unilateral blockade of the m1AChR (pirenzepine, PZP) or m2AChR (methoctramine, MTC) on either side of the POA-AHA on the ovulation rate.
The number of m2AChR-immunoreactive cells was significantly higher at 09:00 h on each day of the oestrous cycle in the POA-AHA region, while no changes in the expression profile of m1AChR protein were observed.
The ovulation rate in rats treated with PZP on the oestrous day was lower than that in the vehicle group.
Animals treated on dioestrous-1 with PZP or MTC had a higher ovulation rate than those in the vehicle group.
In contrast, on dioestrous-2, the MTC treatment decreased the ovulation rate.
These results suggest that m1AChR or m2AChR in the POA-AHA could participate in the regulation of spontaneous ovulation in rats.
American Psychological Association (APA)
López-Ramírez, Yadira L.& López-Ramírez, Kayro& Arrieta-Cruz, Isabel& Flores, Angélica& Mendoza-Garcés, Luciano& Librado-Osorio, Raúl A.…[et al.]. 2017. Muscarinic Receptors Types 1 and 2 in the Preoptic-Anterior Hypothalamic Areas Regulate Ovulation Unequally in the Rat Oestrous Cycle. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166198
Modern Language Association (MLA)
López-Ramírez, Yadira L.…[et al.]. Muscarinic Receptors Types 1 and 2 in the Preoptic-Anterior Hypothalamic Areas Regulate Ovulation Unequally in the Rat Oestrous Cycle. International Journal of Endocrinology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1166198
American Medical Association (AMA)
López-Ramírez, Yadira L.& López-Ramírez, Kayro& Arrieta-Cruz, Isabel& Flores, Angélica& Mendoza-Garcés, Luciano& Librado-Osorio, Raúl A.…[et al.]. Muscarinic Receptors Types 1 and 2 in the Preoptic-Anterior Hypothalamic Areas Regulate Ovulation Unequally in the Rat Oestrous Cycle. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166198