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Melittin Inhibition and Eradication Activity for Resistant Polymicrobial Biofilm Isolated from a Dairy Industry after Disinfection
Joint Authors
Galdiero, Emilia
Siciliano, Antonietta
Gesuele, Renato
Di Onofrio, Valeria
Falanga, Annarita
Maione, Angela
Liguori, Renato
Libralato, Giovanni
Guida, Marco
Source
International Journal of Microbiology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The emerging concern about the increase of antibiotic resistance and associated biofilm has encouraged scientists to look for alternative antibiotics such as antimicrobial peptides (AMPs).
This study evaluated the ability of melittin to act as an antibacterial biofilm inhibitor and biofilm remover considering isolates from dairy industry.
Minimum inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs), minimum biofilm inhibitory concentrations (MBICs), and biofilm removal activities were studied in polymicrobial biofilms produced from isolates.
MIC and MBC were set at 1–3 µg/mL and 25–50 µg/mL for Gram-positive and Gram-negative bacteria, respectively.
Results demonstrated a good MBIC reaching 85% inhibition ability and a good activity and better penetration in deeper layers against the mixed preformed biofilm, thereby increasing its activity against all isolates also at the lowest tested concentrations.
Melittin showed interesting characteristics suggesting its potential to act as an antimicrobial agent for polymicrobial biofilm from dairy industry even in environmental isolates.
American Psychological Association (APA)
Galdiero, Emilia& Siciliano, Antonietta& Gesuele, Renato& Di Onofrio, Valeria& Falanga, Annarita& Maione, Angela…[et al.]. 2019. Melittin Inhibition and Eradication Activity for Resistant Polymicrobial Biofilm Isolated from a Dairy Industry after Disinfection. International Journal of Microbiology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1166208
Modern Language Association (MLA)
Galdiero, Emilia…[et al.]. Melittin Inhibition and Eradication Activity for Resistant Polymicrobial Biofilm Isolated from a Dairy Industry after Disinfection. International Journal of Microbiology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1166208
American Medical Association (AMA)
Galdiero, Emilia& Siciliano, Antonietta& Gesuele, Renato& Di Onofrio, Valeria& Falanga, Annarita& Maione, Angela…[et al.]. Melittin Inhibition and Eradication Activity for Resistant Polymicrobial Biofilm Isolated from a Dairy Industry after Disinfection. International Journal of Microbiology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1166208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166208