Poor Sleep Quality Is Associated with Dawn Phenomenon and Impaired Circadian Clock Gene Expression in Subjects with Type 2 Diabetes Mellitus
Joint Authors
Huang, Yuxin
Wang, Haidong
Li, Yuan
Tao, Xiaoming
Sun, Jiao
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
We investigated whether poor sleep quality is associated with both dawn phenomenon and impaired circadian clock gene expression in subjects with diabetes.
Methods.
81 subjects with diabetes on continuous glucose monitoring were divided into two groups according to the Pittsburgh Sleep Quality Index.
The magnitude of dawn phenomenon was quantified by its increment from nocturnal nadir to prebreakfast.
Peripheral leucocytes were sampled from 81 subjects with diabetes and 28 normal controls at 09:00.
Transcript levels of circadian clock genes (BMAL1, PER1, PER2, and PER3) were determined by real-time quantitative polymerase chain reaction.
Results.
The levels of HbA1c and fasting glucose and the magnitude of dawn phenomenon were significantly higher in the diabetes group with poor sleep quality than that with good sleep quality.
Peripheral leucocytes from subjects with poor sleep quality expressed significantly lower transcript levels of BMAL1 and PER1 compared with those with good sleep quality.
Poor sleep quality was significantly correlated with magnitude of dawn phenomenon.
Multiple linear regression showed that sleep quality and PER1 were significantly independently correlated with dawn phenomenon.
Conclusions.
Dawn phenomenon is associated with sleep quality.
Furthermore, mRNA expression of circadian clock genes is dampened in peripheral leucocytes of subjects with poor sleep quality.
American Psychological Association (APA)
Huang, Yuxin& Wang, Haidong& Li, Yuan& Tao, Xiaoming& Sun, Jiao. 2017. Poor Sleep Quality Is Associated with Dawn Phenomenon and Impaired Circadian Clock Gene Expression in Subjects with Type 2 Diabetes Mellitus. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166218
Modern Language Association (MLA)
Huang, Yuxin…[et al.]. Poor Sleep Quality Is Associated with Dawn Phenomenon and Impaired Circadian Clock Gene Expression in Subjects with Type 2 Diabetes Mellitus. International Journal of Endocrinology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1166218
American Medical Association (AMA)
Huang, Yuxin& Wang, Haidong& Li, Yuan& Tao, Xiaoming& Sun, Jiao. Poor Sleep Quality Is Associated with Dawn Phenomenon and Impaired Circadian Clock Gene Expression in Subjects with Type 2 Diabetes Mellitus. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166218
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166218