The Tissue-Selective Estrogen Complex (BazedoxifeneConjugated Estrogens)‎ for the Treatment of Menopause

Joint Authors

Lello, Stefano
Capozzi, Anna
Scambia, Giovanni

Source

International Journal of Endocrinology

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-12-05

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Biology

Abstract EN

The tissue-selective estrogen complex (TSEC) pairs conjugated estrogens (CE) with a selective estrogen receptor modulator (SERM), bazedoxifene acetate (BZA).

A 2-year treatment with the TSEC improved vasomotor symptoms, quality of life, and vaginal atrophy in healthy postmenopausal women.

In addition, the TSEC prevented vertebral and hip bone loss without increasing mammographic density, breast tenderness, the risk of myocardial infarction, stroke, or venous thromboembolism.

Finally, the BZA 20 mg/CE 0.45 mg dose did not increase the risk of endometrial hyperplasia.

Based on these findings, the TSEC can be considered as a first-line treatment for symptomatic postmenopausal women.

American Psychological Association (APA)

Lello, Stefano& Capozzi, Anna& Scambia, Giovanni. 2017. The Tissue-Selective Estrogen Complex (BazedoxifeneConjugated Estrogens) for the Treatment of Menopause. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166402

Modern Language Association (MLA)

Lello, Stefano…[et al.]. The Tissue-Selective Estrogen Complex (BazedoxifeneConjugated Estrogens) for the Treatment of Menopause. International Journal of Endocrinology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1166402

American Medical Association (AMA)

Lello, Stefano& Capozzi, Anna& Scambia, Giovanni. The Tissue-Selective Estrogen Complex (BazedoxifeneConjugated Estrogens) for the Treatment of Menopause. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166402

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1166402