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Latent Inflammation and Insulin Resistance in Adipose Tissue
Joint Authors
Ratner, E.
Menshikov, M.
Parfyonova, Ye.
Stafeev, I. S.
Vorotnikov, A. V.
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Obesity is a growing problem in modern society and medicine.
It closely associates with metabolic disorders such as type 2 diabetes mellitus (T2DM) and hepatic and cardiovascular diseases such as nonalcoholic fatty liver disease, atherosclerosis, myocarditis, and hypertension.
Obesity is often associated with latent inflammation; however, the link between inflammation, obesity, T2DM, and cardiovascular diseases is still poorly understood.
Insulin resistance is the earliest feature of metabolic disorders.
It mostly develops as a result of dysregulated insulin signaling in insulin-sensitive cells, as compared to inactivating mutations in insulin receptor or signaling proteins that occur relatively rare.
Here, we argue that inflammatory signaling provides a link between latent inflammation, obesity, insulin resistance, and metabolic disorders.
We further hypothesize that insulin-activated PI3-kinase pathway and inflammatory signaling mediated by several IκB kinases may constitute negative feedback leading to insulin resistance at least in the fat tissue.
Finally, we discuss perspectives for anti-inflammatory therapies in treating the metabolic diseases.
American Psychological Association (APA)
Stafeev, I. S.& Vorotnikov, A. V.& Ratner, E.& Menshikov, M.& Parfyonova, Ye.. 2017. Latent Inflammation and Insulin Resistance in Adipose Tissue. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1166406
Modern Language Association (MLA)
Stafeev, I. S.…[et al.]. Latent Inflammation and Insulin Resistance in Adipose Tissue. International Journal of Endocrinology No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1166406
American Medical Association (AMA)
Stafeev, I. S.& Vorotnikov, A. V.& Ratner, E.& Menshikov, M.& Parfyonova, Ye.. Latent Inflammation and Insulin Resistance in Adipose Tissue. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1166406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166406