Elevated Squamous Cell Carcinoma Antigen, Cytokeratin 19 Fragment, and Carcinoembryonic Antigen Levels in Diabetic Nephropathy
Joint Authors
Tao, Feng
Chen, Qingguang
Chen, Jianzhong
Zhang, Bin
Qiu, Yan
Luo, Qian
Gen, Yanna
Meng, Jiali
Zhang, Jue
Lu, Hao
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
We aimed to explore whether squamous cell carcinoma antigen (SCC), cytokeratin 19 fragment (Cyfra21-1), neuron-specific enolase (NSE), and carcinoembryonic antigen (CEA) are elevated in diabetic nephropathy (DN) and the association between urinary albumin-to-creatinine ratio (UACR) and tumor markers in diabetic patients.
Methods.
Nondialysis patients with diabetes (n=261) and 90 healthy controls were enrolled.
DN was defined as an UACR ≥ 30 mg/g in the absence of a urinary tract infection or other renal abnormalities.
Results.
Patients with DN had significantly higher serum SCC, Cyfra21-1, and CEA levels than those with normoalbuminuria and healthy controls.
The rates of positive SCC, Cyfra21-1, and CEA significantly increased with increasing urinary albumin excretion (all P for trend < 0.001).
In contrast, NSE was not affected by DN.
SCC, Cyfra21-1, and CEA were significantly and positively correlated with UACR.
In logistic regression, after multivariable adjustment, increased UACR was associated with increased odds ratio of elevated tumor marker levels (all P for trend < 0.05).
Conclusions.
Serum levels of SCC, Cyfra21-1, and CEA are markedly increased with increasing urinary albumin excretion, which affects the specificity for diagnosis for lung cancer.
Appropriate interpretation of tumor markers in diabetic patients is mandatory to avoid unnecessary and even hazardous biopsies.
American Psychological Association (APA)
Chen, Jianzhong& Tao, Feng& Zhang, Bin& Chen, Qingguang& Qiu, Yan& Luo, Qian…[et al.]. 2017. Elevated Squamous Cell Carcinoma Antigen, Cytokeratin 19 Fragment, and Carcinoembryonic Antigen Levels in Diabetic Nephropathy. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1166411
Modern Language Association (MLA)
Chen, Jianzhong…[et al.]. Elevated Squamous Cell Carcinoma Antigen, Cytokeratin 19 Fragment, and Carcinoembryonic Antigen Levels in Diabetic Nephropathy. International Journal of Endocrinology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1166411
American Medical Association (AMA)
Chen, Jianzhong& Tao, Feng& Zhang, Bin& Chen, Qingguang& Qiu, Yan& Luo, Qian…[et al.]. Elevated Squamous Cell Carcinoma Antigen, Cytokeratin 19 Fragment, and Carcinoembryonic Antigen Levels in Diabetic Nephropathy. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1166411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166411