Relationship between IGF-I Concentration and Metabolic Profile in Children with Growth Hormone Deficiency: The Influence of Children’s Nutritional State as well as the Ghrelin, Leptin, Adiponectin, and Resistin Serum Concentrations
Joint Authors
Lewiński, Andrzej
Stawerska, Renata
Smyczyńska, Joanna
Hilczer, Maciej
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Some, however not all, children with growth hormone deficiency (GHD) reveal a tendency towards metabolic disorders.
Insulin-like growth factor I (IGF-I) is the main mediator of GH anabolic effects.
Objective.
The aim of the study was to compare ghrelin, adiponectin, leptin, resistin, lipid, glucose, and insulin concentrations in GHD children, depending on the IGF-I bioavailability.
Methods.
The analysis comprised 26 children with GHD, aged 5.7–15.3 yrs.
Fasting serum concentrations of IGF-I, IGFBP-3, ghrelin, leptin, adiponectin, resistin, lipids, glucose, and insulin were measured.
The GHD children were divided into two subgroups: (1) with lower IGF-I/IGFBP-3 molar ratio and (2) with higher IGF-I/IGFBP-3 molar ratio.
The control group consisted of 39 healthy children, aged 5.1–16.6 yrs, of normal height and body mass.
Results.
GHD children with lower IGF-I/IGFBP-3 molar ratio were found to have a significantly lower body mass and insulin and triglyceride concentrations, as well as significantly higher ghrelin and adiponectin concentrations than GHD children with higher IGF-I/IGFBP-3.
Conclusions.
A better metabolic profile characterised GHD children with low IGF-I bioavailability.
This phenomenon may be the result of high adiponectin and ghrelin concentrations in those children and their influence on adipose tissue, glucose uptake, and orexigenic axis.
American Psychological Association (APA)
Stawerska, Renata& Smyczyńska, Joanna& Hilczer, Maciej& Lewiński, Andrzej. 2017. Relationship between IGF-I Concentration and Metabolic Profile in Children with Growth Hormone Deficiency: The Influence of Children’s Nutritional State as well as the Ghrelin, Leptin, Adiponectin, and Resistin Serum Concentrations. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166439
Modern Language Association (MLA)
Stawerska, Renata…[et al.]. Relationship between IGF-I Concentration and Metabolic Profile in Children with Growth Hormone Deficiency: The Influence of Children’s Nutritional State as well as the Ghrelin, Leptin, Adiponectin, and Resistin Serum Concentrations. International Journal of Endocrinology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1166439
American Medical Association (AMA)
Stawerska, Renata& Smyczyńska, Joanna& Hilczer, Maciej& Lewiński, Andrzej. Relationship between IGF-I Concentration and Metabolic Profile in Children with Growth Hormone Deficiency: The Influence of Children’s Nutritional State as well as the Ghrelin, Leptin, Adiponectin, and Resistin Serum Concentrations. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166439
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166439