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Myoinositol: The Bridge (PONTI) to Reach a Healthy Pregnancy
Joint Authors
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The use of folic acid in the periconceptional period can prevent about 70% of neural tube defects (NTDs).
In the remaining cases, no medical prevention is available, and those conditions should be defined as folate-resistant NTDs.
Rodent models suggest that some folate-resistant NTDs can be prevented by inositol (myoinositol and chiroinositol) supplementation prior to pregnancy.
Should folic acid be combined with myoinositol periconceptional supplementation to reduce the overall risk of NTDs even in humans? Hereafter, we discuss the results from the PONTI study that strongly support both the effectiveness and safety of myoinositol periconceptional supplementation in preventing human NTDs.
We further report on the largest case series of pregnancies treated with myoinositol and folic acid.
At our institution, a sequential study during 12 years involved mothers at risk of fetal NTDs, and 29 babies from 27 pregnancies were born after periconceptional combined myoinositol and folic acid supplementation.
No case of NTDs was observed, despite the high recurrence risk in the mothers.
Taken together, those data suggest that periconceptional folic acid plus myoinositol can reduce both the occurrence and recurrence risks of NTDs in a greater number of cases than folic acid alone.
American Psychological Association (APA)
Cavalli, Pietro& Ronda, Elena. 2017. Myoinositol: The Bridge (PONTI) to Reach a Healthy Pregnancy. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1166449
Modern Language Association (MLA)
Cavalli, Pietro& Ronda, Elena. Myoinositol: The Bridge (PONTI) to Reach a Healthy Pregnancy. International Journal of Endocrinology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1166449
American Medical Association (AMA)
Cavalli, Pietro& Ronda, Elena. Myoinositol: The Bridge (PONTI) to Reach a Healthy Pregnancy. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1166449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166449